THE GLUCAN PARTICLES AS POTENTIAL CARRIERS FOR ANTI-INFLAMMATORY DRUGS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F19%3A43919865" target="_blank" >RIV/60461373:22340/19:43919865 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22340/19:43919873

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

THE GLUCAN PARTICLES AS POTENTIAL CARRIERS FOR ANTI-INFLAMMATORY DRUGS

Popis výsledku v původním jazyce

Introduction: One of the novel methods of pharmaceutical formulation is the loading of the drug into biocompatible microparticles, preferably extracted from natural sources. This approach offers several potential advantages compared to conventional drug delivery methods, enabling the option of oral administration even for wider group of drugs. Multiple principles of the loading process are possible – adsorption onto the particle surface or precipitation inside the pores of a hollow particle. The presented work focuses on precipitation of a drug from an organic solvent inside microparticles - glucan particles. Glucan particles (GPs) are ellipsoid porous shells, which are obtained from cells of Saccharomyces cerevisiae (baker’s yeast). The particle size is 2-5 micrometers. Cell walls of glucan particles are mainly composed of β-1,3-glucans. GPs can be used as a vehicle, since β-1,3-glucan can interact with immune system in organism, especially with lymphatic cells. Lymphatic cells are mainly present in inflammation areas in organism where they play an important role in the process of inflammation. GPs interact with lymphatic cell’s receptors on their surface and after that GPs are phagocytosed by the lymphatic cells. Prepared GPs can be loaded with various active compounds, including natural substances and then deliver their content into the target area - in this case in the inflamed area. Therefore, GPs can represent an effective delivery system of biological active substances. The other advantage of GPs is that they can be deliver to organism per os. In this project curcumin was tested due to its anti-inflammatory activity. Curcumin is an antioxidant and anti-inflammatory flavonoid, which occurs in plants of family Zingiberacaea. Loading of curcumin into GPs was enabled via precipitation of curcumin from organic solvents using controlled evaporation method. The GPs loaded with anti-inflammatory drugs can be used as potential treatment in inflammatory bowel diseases such Crohn’s disease and ulcerous colitis.

Název v anglickém jazyce

THE GLUCAN PARTICLES AS POTENTIAL CARRIERS FOR ANTI-INFLAMMATORY DRUGS

Popis výsledku anglicky

Introduction: One of the novel methods of pharmaceutical formulation is the loading of the drug into biocompatible microparticles, preferably extracted from natural sources. This approach offers several potential advantages compared to conventional drug delivery methods, enabling the option of oral administration even for wider group of drugs. Multiple principles of the loading process are possible – adsorption onto the particle surface or precipitation inside the pores of a hollow particle. The presented work focuses on precipitation of a drug from an organic solvent inside microparticles - glucan particles. Glucan particles (GPs) are ellipsoid porous shells, which are obtained from cells of Saccharomyces cerevisiae (baker’s yeast). The particle size is 2-5 micrometers. Cell walls of glucan particles are mainly composed of β-1,3-glucans. GPs can be used as a vehicle, since β-1,3-glucan can interact with immune system in organism, especially with lymphatic cells. Lymphatic cells are mainly present in inflammation areas in organism where they play an important role in the process of inflammation. GPs interact with lymphatic cell’s receptors on their surface and after that GPs are phagocytosed by the lymphatic cells. Prepared GPs can be loaded with various active compounds, including natural substances and then deliver their content into the target area - in this case in the inflamed area. Therefore, GPs can represent an effective delivery system of biological active substances. The other advantage of GPs is that they can be deliver to organism per os. In this project curcumin was tested due to its anti-inflammatory activity. Curcumin is an antioxidant and anti-inflammatory flavonoid, which occurs in plants of family Zingiberacaea. Loading of curcumin into GPs was enabled via precipitation of curcumin from organic solvents using controlled evaporation method. The GPs loaded with anti-inflammatory drugs can be used as potential treatment in inflammatory bowel diseases such Crohn’s disease and ulcerous colitis.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20401 - Chemical engineering (plants, products)

Projekt

<a href="/cs/project/NV16-27522A" target="_blank" >NV16-27522A: Přírodní bioaktivní látky enkapsulované v glukanových mikročásticích jako biomateriál vhodný pro léčbu střevních zánětlivých onemocnění</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů