Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F21%3A43922869" target="_blank" >RIV/60461373:22340/21:43922869 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00027162:_____/21:N0000017 RIV/61989592:15640/21:73607286 RIV/00216224:14160/21:00124219

Výsledek na webu

<a href="https://doi.org/10.1016/j.ijbiomac.2020.12.107" target="_blank" >https://doi.org/10.1016/j.ijbiomac.2020.12.107</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijbiomac.2020.12.107" target="_blank" >10.1016/j.ijbiomac.2020.12.107</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro

Popis výsledku v původním jazyce

Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs. GPs possess their own biological activities and can act synergistically with their cargo. This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro. Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared. Several of the natural compounds showed the beneficial effects of being combined with GPs. The materials prepared by spray drying showed greater activity than those made using a rotary evaporator. Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α. © 2020 Elsevier B.V.

Název v anglickém jazyce

Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro

Popis výsledku anglicky

Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs. GPs possess their own biological activities and can act synergistically with their cargo. This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro. Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared. Several of the natural compounds showed the beneficial effects of being combined with GPs. The materials prepared by spray drying showed greater activity than those made using a rotary evaporator. Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α. © 2020 Elsevier B.V.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20401 - Chemical engineering (plants, products)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Biological Macromolecules

ISSN

0141-8130

e-ISSN

—

Svazek periodika

169

Číslo periodika v rámci svazku

February 2021

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

443-451

Kód UT WoS článku

000609211300044

EID výsledku v databázi Scopus

2-s2.0-85098189491