Simulation of Complex Biomolecular Systems: The Ribosome Challenge
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F23%3A43927813" target="_blank" >RIV/60461373:22340/23:43927813 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.annualreviews.org/doi/10.1146/annurev-biophys-111622-091147#_i24" target="_blank" >https://www.annualreviews.org/doi/10.1146/annurev-biophys-111622-091147#_i24</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1146/annurev-biophys-111622-091147" target="_blank" >10.1146/annurev-biophys-111622-091147</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Simulation of Complex Biomolecular Systems: The Ribosome Challenge
Popis výsledku v původním jazyce
Large biomolecular systems are at the heart of many essential cellular processes. The dynamics and energetics of an increasing number of these systems are being studied by computer simulations. Pushing the limits of length- and timescales that can be accessed by current hard- and software has expanded the ability to describe biomolecules at different levels of detail. We focus in this review on the ribosome, which exemplifies the close interplay between experiment and various simulation approaches, as a particularly challenging and prototypic nanomachine that is pivotal to cellular biology due to its central role in translation. We sketch widely used simulation methods and demonstrate how the combination of simulations and experiments advances our understanding of the function of the translation apparatus based on fundamental physics. © 2023 by the author(s).
Název v anglickém jazyce
Simulation of Complex Biomolecular Systems: The Ribosome Challenge
Popis výsledku anglicky
Large biomolecular systems are at the heart of many essential cellular processes. The dynamics and energetics of an increasing number of these systems are being studied by computer simulations. Pushing the limits of length- and timescales that can be accessed by current hard- and software has expanded the ability to describe biomolecules at different levels of detail. We focus in this review on the ribosome, which exemplifies the close interplay between experiment and various simulation approaches, as a particularly challenging and prototypic nanomachine that is pivotal to cellular biology due to its central role in translation. We sketch widely used simulation methods and demonstrate how the combination of simulations and experiments advances our understanding of the function of the translation apparatus based on fundamental physics. © 2023 by the author(s).
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10610 - Biophysics
Návaznosti výsledku
Projekt
<a href="/cs/project/GJ19-06479Y" target="_blank" >GJ19-06479Y: Struktura a dynamika peptidového tunelu v ribozomu</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Annual Review of Biophysics
ISSN
1936-122X
e-ISSN
—
Svazek periodika
52
Číslo periodika v rámci svazku
May
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
30
Strana od-do
361-390
Kód UT WoS článku
000982017100017
EID výsledku v databázi Scopus
2-s2.0-85159563407