Neinvazivní technika ředění deuteria pro měření celkové tělesné vody pacientů léčených haemodialýzou

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F08%3A00314995" target="_blank" >RIV/61388955:_____/08:00314995 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A non-invasive, on-line deuterium dilution technique for the measurement of total body water in haemodialysis patients

Popis výsledku v původním jazyce

Background: Despite its importance, total body water (TBW) is usually estimated rather than measured due to the complexity of isotope dilution methods. The aim of this study was to demonstrate the applicability in haemodialysis (HD) patients of a recently developed on-line breath test, previously validated in healthy subjects, that uses the gold standard deuterium dilution method to measure TBW. In particular we wished to show that a pre-dialysis estimation was as good as a post-dialysis equilibrated measurement in order to avoid patients needing to remain behind after dialysis treatment. Methods: The dispersal kinetics of breath HDO, measured using a flowing afterglow mass spectrometer (FA-MS) following ingestion of D2O immediately post-dialysis, weredetermined in 12 haemodialysis patients and used to calculate the absolute TBWPostHD after full equilibration. TBWPreHD was then determined from breath samples taken immediately prior to the next dialysis.

Název v anglickém jazyce

A non-invasive, on-line deuterium dilution technique for the measurement of total body water in haemodialysis patients

Popis výsledku anglicky

Background: Despite its importance, total body water (TBW) is usually estimated rather than measured due to the complexity of isotope dilution methods. The aim of this study was to demonstrate the applicability in haemodialysis (HD) patients of a recently developed on-line breath test, previously validated in healthy subjects, that uses the gold standard deuterium dilution method to measure TBW. In particular we wished to show that a pre-dialysis estimation was as good as a post-dialysis equilibrated measurement in order to avoid patients needing to remain behind after dialysis treatment. Methods: The dispersal kinetics of breath HDO, measured using a flowing afterglow mass spectrometer (FA-MS) following ingestion of D2O immediately post-dialysis, weredetermined in 12 haemodialysis patients and used to calculate the absolute TBWPostHD after full equilibration. TBWPreHD was then determined from breath samples taken immediately prior to the next dialysis.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nephrology Dialysis Transplantation

ISSN

0931-0509

e-ISSN

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Svazek periodika

23

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

000256173300045

EID výsledku v databázi Scopus

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