Breath Analysis and the Measurement of Total Body Water Using Isotope Dilution - Applications in the Dialysis Clinic

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F13%3A00397720" target="_blank" >RIV/61388955:_____/13:00397720 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.2174/15734110113099990024" target="_blank" >http://dx.doi.org/10.2174/15734110113099990024</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/15734110113099990024" target="_blank" >10.2174/15734110113099990024</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Breath Analysis and the Measurement of Total Body Water Using Isotope Dilution - Applications in the Dialysis Clinic

Popis výsledku v původním jazyce

Determination of fluid status in patients suffering from kidney failure presents particular challenges. In addition to the failure of homeostatic mechanisms controlling fluid status their chronic disease and associated comorbid conditions disturb body composition, for example by causing muscle wasting or obesity. Accurate assessment of fluid status at the bedside would likely inform better clinical decision making. To facilitate this, a near patient method for determining the total body water (TBW) wasdeveloped. Following ingestion of a known amount of D2O, which equilibrates as HDO the TBWD is determined using the dilution principle. Flowing afterglow mass spectrometry accurately measures the concentration of HDO in either breath or the headspace offluids (e.g. dialysate) enabling immediate calculation of TBW without the need for laboratory measurements. A series of clinical studies was undertaken to establish the validity of the method, especially for longitudinal measurements and

Název v anglickém jazyce

Breath Analysis and the Measurement of Total Body Water Using Isotope Dilution - Applications in the Dialysis Clinic

Popis výsledku anglicky

Determination of fluid status in patients suffering from kidney failure presents particular challenges. In addition to the failure of homeostatic mechanisms controlling fluid status their chronic disease and associated comorbid conditions disturb body composition, for example by causing muscle wasting or obesity. Accurate assessment of fluid status at the bedside would likely inform better clinical decision making. To facilitate this, a near patient method for determining the total body water (TBW) wasdeveloped. Following ingestion of a known amount of D2O, which equilibrates as HDO the TBWD is determined using the dilution principle. Flowing afterglow mass spectrometry accurately measures the concentration of HDO in either breath or the headspace offluids (e.g. dialysate) enabling immediate calculation of TBW without the need for laboratory measurements. A series of clinical studies was undertaken to establish the validity of the method, especially for longitudinal measurements and

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

<a href="/cs/project/GA203%2F00%2F0632" target="_blank" >GA203/00/0632: Chemie iontů v plynné fázi a ve srážkách s povrchy</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Analytical Chemistry

ISSN

1573-4110

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

593-599

Kód UT WoS článku

000324493100009

EID výsledku v databázi Scopus

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