Electrochemical Study of Highly Substituted Titanocene Dihalides
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F19%3A00508037" target="_blank" >RIV/61388955:_____/19:00508037 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00209805:_____/19:00078257 RIV/00216208:11310/19:10404405
Výsledek na webu
<a href="http://hdl.handle.net/11104/0298992" target="_blank" >http://hdl.handle.net/11104/0298992</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/elan.201900464" target="_blank" >10.1002/elan.201900464</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Electrochemical Study of Highly Substituted Titanocene Dihalides
Popis výsledku v původním jazyce
Titanocene dihalides are promising alternative to Cisplatin in cancer chemotherapy which should reduce negative side effects and overcome increasing resistance of cancer cells. Since the mechanism of anti-cancer action is associated with generation of reactive oxygen species (ROS), hence with redox processes, electrochemical investigation of titanocene species would be an important issue, not applied up to now. In this article we report on the electrochemical reduction as well as oxidation of titanocene difluorides and dichlorides where unsubstituted as well as highly substituted titanocene dihalides are compared. The experiments were realized in acetonitrile using various electrode materials. The studied series was completed by a new dimethylsilylene bridged ansa-titanocene difluoride which was characterized by NMR and x-ray crystallography. The influence of structure and substitution on the redox properties was evaluated and, in addition to this, cytotoxicity of studied titanocene dihalides against human ovarian cancer cell lines A2780 and SK-OV-3, as well as against human embryonic kidney cell line HEK293 were screened. Two of highly substituted titanocenes exhibit cytotoxicity comparable with that of Cisplatin.
Název v anglickém jazyce
Electrochemical Study of Highly Substituted Titanocene Dihalides
Popis výsledku anglicky
Titanocene dihalides are promising alternative to Cisplatin in cancer chemotherapy which should reduce negative side effects and overcome increasing resistance of cancer cells. Since the mechanism of anti-cancer action is associated with generation of reactive oxygen species (ROS), hence with redox processes, electrochemical investigation of titanocene species would be an important issue, not applied up to now. In this article we report on the electrochemical reduction as well as oxidation of titanocene difluorides and dichlorides where unsubstituted as well as highly substituted titanocene dihalides are compared. The experiments were realized in acetonitrile using various electrode materials. The studied series was completed by a new dimethylsilylene bridged ansa-titanocene difluoride which was characterized by NMR and x-ray crystallography. The influence of structure and substitution on the redox properties was evaluated and, in addition to this, cytotoxicity of studied titanocene dihalides against human ovarian cancer cell lines A2780 and SK-OV-3, as well as against human embryonic kidney cell line HEK293 were screened. Two of highly substituted titanocenes exhibit cytotoxicity comparable with that of Cisplatin.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Electroanalysis
ISSN
1040-0397
e-ISSN
—
Svazek periodika
31
Číslo periodika v rámci svazku
10
Stát vydavatele periodika
DE - Spolková republika Německo
Počet stran výsledku
7
Strana od-do
2067-2073
Kód UT WoS článku
000480994500001
EID výsledku v databázi Scopus
2-s2.0-85070892461