Identification and interconversion of diastereomeric oligo-Troger bases probed by ion mobility mass spectrometry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00379208" target="_blank" >RIV/61388963:_____/12:00379208 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22340/12:43893268

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c2cp40585g" target="_blank" >http://dx.doi.org/10.1039/c2cp40585g</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c2cp40585g" target="_blank" >10.1039/c2cp40585g</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Identification and interconversion of diastereomeric oligo-Troger bases probed by ion mobility mass spectrometry

Popis výsledku v původním jazyce

Oligo-Troger bases are auspicious scaffolds of molecular engineering, which motivates studies on the mechanism of their interconversion and on the facile determination of the relative configuration of their diastereoisomers. Protonated, sodiated, and argentated species of those compounds were therefore studied via ion-mobility mass spectrometry (IM-MS), allowing differentiation on the basis of the shapes of the ions. First, the isomerization was confirmed to be acid-catalyzed as it takes place readily in the case of protonated Troger bases, whereas the metallated bases are configurationally stable. Second, the corrected arrival times of the various isomers of the cationized bases were found to show distinct differences in IM-MS, and their excellent correlation with the cross sections obtained from quantum chemical calculations paves the way toward the easy identification of diastereoisomers.

Název v anglickém jazyce

Identification and interconversion of diastereomeric oligo-Troger bases probed by ion mobility mass spectrometry

Popis výsledku anglicky

Oligo-Troger bases are auspicious scaffolds of molecular engineering, which motivates studies on the mechanism of their interconversion and on the facile determination of the relative configuration of their diastereoisomers. Protonated, sodiated, and argentated species of those compounds were therefore studied via ion-mobility mass spectrometry (IM-MS), allowing differentiation on the basis of the shapes of the ions. First, the isomerization was confirmed to be acid-catalyzed as it takes place readily in the case of protonated Troger bases, whereas the metallated bases are configurationally stable. Second, the corrected arrival times of the various isomers of the cationized bases were found to show distinct differences in IM-MS, and their excellent correlation with the cross sections obtained from quantum chemical calculations paves the way toward the easy identification of diastereoisomers.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA203%2F08%2F1445" target="_blank" >GA203/08/1445: Funkční molekulární pinzety na principu bis Trögerových bazí</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physical Chemistry Chemical Physics

ISSN

1463-9076

e-ISSN

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Svazek periodika

14

Číslo periodika v rámci svazku

19

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

6987-6995

Kód UT WoS článku

000303251100035

EID výsledku v databázi Scopus

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