Application of UV-Vis spectrophotometric and chemiluminescent methods for the evaluation of the antioxidant action of curcumin
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00383640" target="_blank" >RIV/61388963:_____/12:00383640 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.2298/JSC110621032S" target="_blank" >http://dx.doi.org/10.2298/JSC110621032S</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2298/JSC110621032S" target="_blank" >10.2298/JSC110621032S</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Application of UV-Vis spectrophotometric and chemiluminescent methods for the evaluation of the antioxidant action of curcumin
Popis výsledku v původním jazyce
Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is a natural biologically active substance with antioxidant activity. The ability of curcumin to inhibit free radical reactions can be used in the prevention of diseases such as cancer and coronary heart disease. UV-Vis spectrophotometric and chemiluminescent dynamic methods for determination of the antioxidant activity of curcumin were developed. The spectrophotometric method includes investigation of the interaction between DNA, isolated from HL-60 cells, and curcumin. The decreasing absorption of curcumin in the presence of HL-60 DNA against the blank sample can be a measurement for some complex formation between curcumin and DNA. The chemiluminescent method involves three testsfor the detection of luminol- dependent chemiluminescence based on model systems that generate superoxide, hydroxide and hypochlorite radicals. The strongest decay of chemilunimescence was registered at the highest concentration of curcum
Název v anglickém jazyce
Application of UV-Vis spectrophotometric and chemiluminescent methods for the evaluation of the antioxidant action of curcumin
Popis výsledku anglicky
Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is a natural biologically active substance with antioxidant activity. The ability of curcumin to inhibit free radical reactions can be used in the prevention of diseases such as cancer and coronary heart disease. UV-Vis spectrophotometric and chemiluminescent dynamic methods for determination of the antioxidant activity of curcumin were developed. The spectrophotometric method includes investigation of the interaction between DNA, isolated from HL-60 cells, and curcumin. The decreasing absorption of curcumin in the presence of HL-60 DNA against the blank sample can be a measurement for some complex formation between curcumin and DNA. The chemiluminescent method involves three testsfor the detection of luminol- dependent chemiluminescence based on model systems that generate superoxide, hydroxide and hypochlorite radicals. The strongest decay of chemilunimescence was registered at the highest concentration of curcum
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CC - Organická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of the Serbian Chemical Society
ISSN
0352-5139
e-ISSN
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Svazek periodika
77
Číslo periodika v rámci svazku
8
Stát vydavatele periodika
RS - Srbská republika
Počet stran výsledku
7
Strana od-do
1063-1069
Kód UT WoS článku
000308830900008
EID výsledku v databázi Scopus
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