G Protein Regulation of Neuronal Calcium Channels: Back to the Future

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F15%3A00444642" target="_blank" >RIV/61388963:_____/15:00444642 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1124/mol.114.096008" target="_blank" >http://dx.doi.org/10.1124/mol.114.096008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1124/mol.114.096008" target="_blank" >10.1124/mol.114.096008</a>

Jazyk výsledku

angličtina

Název v původním jazyce

G Protein Regulation of Neuronal Calcium Channels: Back to the Future

Popis výsledku v původním jazyce

Neuronal voltage-gated calcium channels have evolved as one of the most important players for calcium entry into presynaptic endings responsible for the release of neurotransmitters. In turn, and to fine-tune synaptic activity and neuronal communication,numerous neurotransmitters exert a potent negative feedback over the calcium signal provided by G protein-coupled receptors. This regulation pathway of physiologic importance is also extensively exploited for therapeutic purposes, for instance in the treatment of neuropathic pain by morphine and other mu-opioid receptor agonists. However, despite more than three decades of intensive research, important questions remain unsolved regarding the molecular and cellular mechanisms of direct G protein inhibition of voltage-gated calcium channels. In this study, we revisit this particular regulation and explore new considerations.

Název v anglickém jazyce

G Protein Regulation of Neuronal Calcium Channels: Back to the Future

Popis výsledku anglicky

Neuronal voltage-gated calcium channels have evolved as one of the most important players for calcium entry into presynaptic endings responsible for the release of neurotransmitters. In turn, and to fine-tune synaptic activity and neuronal communication,numerous neurotransmitters exert a potent negative feedback over the calcium signal provided by G protein-coupled receptors. This regulation pathway of physiologic importance is also extensively exploited for therapeutic purposes, for instance in the treatment of neuropathic pain by morphine and other mu-opioid receptor agonists. However, despite more than three decades of intensive research, important questions remain unsolved regarding the molecular and cellular mechanisms of direct G protein inhibition of voltage-gated calcium channels. In this study, we revisit this particular regulation and explore new considerations.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA15-13556S" target="_blank" >GA15-13556S: Patofysiologie vápníkových kanálů T-typu u diabetické neuropatie</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular Pharmacology

ISSN

0026-895X

e-ISSN

—

Svazek periodika

87

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

17

Strana od-do

890-906

Kód UT WoS článku

000354617000001

EID výsledku v databázi Scopus

2-s2.0-84936136177