Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves of Buddleja saligna Willd

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F16%3A00458543" target="_blank" >RIV/61388963:_____/16:00458543 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.3109/14756366.2014.1003927" target="_blank" >http://dx.doi.org/10.3109/14756366.2014.1003927</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/14756366.2014.1003927" target="_blank" >10.3109/14756366.2014.1003927</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves of Buddleja saligna Willd

Popis výsledku v původním jazyce

In our continuing search for biologically active natural product(s) of plant origin, Buddleja saligna, a South African medicinal plant, was screened in line with its traditional use for antidiabetic (yeast alpha glucosidase inhibitory) and antiplasmodial (against a chloroquine sensitive strain of Plasmodium falciparum (NF54)) activities. The hexane fraction showed the most promising activity with regards to its antidiabetic (IC50=260 +/- 0.112 mu g/ml) and antiplasmodial (IC50=8.5 +/- 1.6 mu g/ml) activities. Using activity guided fractionation three known terpenoids (betulonic acid, betulone and spinasterol) were isolated from this species for the first time. The compounds displayed varying levels of biological activities (antidiabetic: 27.31 mu g/ml >= C-50 >= 5.6 mu g/ml; antiplasmodial: 14 mu g/ml >= C-50 >= 2 mu g/ml) with very minimal toxicity.

Název v anglickém jazyce

Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves of Buddleja saligna Willd

Popis výsledku anglicky

In our continuing search for biologically active natural product(s) of plant origin, Buddleja saligna, a South African medicinal plant, was screened in line with its traditional use for antidiabetic (yeast alpha glucosidase inhibitory) and antiplasmodial (against a chloroquine sensitive strain of Plasmodium falciparum (NF54)) activities. The hexane fraction showed the most promising activity with regards to its antidiabetic (IC50=260 +/- 0.112 mu g/ml) and antiplasmodial (IC50=8.5 +/- 1.6 mu g/ml) activities. Using activity guided fractionation three known terpenoids (betulonic acid, betulone and spinasterol) were isolated from this species for the first time. The compounds displayed varying levels of biological activities (antidiabetic: 27.31 mu g/ml >= C-50 >= 5.6 mu g/ml; antiplasmodial: 14 mu g/ml >= C-50 >= 2 mu g/ml) with very minimal toxicity.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Enzyme Inhibition and Medicinal Chemistry

ISSN

1475-6366

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

63-66

Kód UT WoS článku

000367555300007

EID výsledku v databázi Scopus

2-s2.0-84953292273