Transforming parasites into their own foes: parasitic extracellular vesicles as a vaccine platform

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00576245" target="_blank" >RIV/61388963:_____/23:00576245 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.pt.2023.08.009" target="_blank" >https://doi.org/10.1016/j.pt.2023.08.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pt.2023.08.009" target="_blank" >10.1016/j.pt.2023.08.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Transforming parasites into their own foes: parasitic extracellular vesicles as a vaccine platform

Popis výsledku v původním jazyce

Parasitic diseases continue to afflict millions of people globally. However, traditional vaccine development strategies are often difficult to apply to parasites, leaving an immense unmet need for new effective vaccines for the prevention and control of parasitic infections. As parasites commonly use extracellular vesicles (EVs) to interact with, interfere with, or modulate the host immune response from a distance, parasite-derived EVs may provide promising vaccine agents that induce immunity against parasitic infections. We here present achievements to date and the challenges and limitations associated with using parasitic EVs in a clinical context. Despite the many difficulties that need to be overcome, we believe this direction could offer a new and reliable source of therapeutics for various neglected parasitic diseases.

Název v anglickém jazyce

Transforming parasites into their own foes: parasitic extracellular vesicles as a vaccine platform

Popis výsledku anglicky

Parasitic diseases continue to afflict millions of people globally. However, traditional vaccine development strategies are often difficult to apply to parasites, leaving an immense unmet need for new effective vaccines for the prevention and control of parasitic infections. As parasites commonly use extracellular vesicles (EVs) to interact with, interfere with, or modulate the host immune response from a distance, parasite-derived EVs may provide promising vaccine agents that induce immunity against parasitic infections. We here present achievements to date and the challenges and limitations associated with using parasitic EVs in a clinical context. Despite the many difficulties that need to be overcome, we believe this direction could offer a new and reliable source of therapeutics for various neglected parasitic diseases.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Trends in Parasitology

ISSN

1471-4922

e-ISSN

1471-5007

Svazek periodika

39

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

16

Strana od-do

913-928

Kód UT WoS článku

001098952200001

EID výsledku v databázi Scopus

2-s2.0-85172161275