A new role of sigma factors in regulation of bacterial transcription

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00581866" target="_blank" >RIV/61388963:_____/23:00581866 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/23:00581866 RIV/68378050:_____/23:00581866

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A new role of sigma factors in regulation of bacterial transcription

Popis výsledku v původním jazyce

Bacterial gene expression is controlled by sigma (σ) factors, that bind to RNA polymerase (RNAP), recognize specific promoter sequences in DNA, and mediate transcription initiation. Bacteria always contain one primary or so called “housekeeping” σ factor. In the gram-positive antibiotic producing bacterium, Streptomyces coelicolor, 65 genes encoding different σ factors are found. HrdB is the main sigma factor in S. coelicolor and is responsible for expression of essential genes. On the other hand, genes that are required in different stresses or environmental conditions are regulated by alternative σ factors. Alternative σ factors are typically about half the size (~30 kDa) of HrdB and lack some of its domains. These factors recognize promoter consensus sequences different from HrdB. They are responsible for transcription of gene subsets with specific functions1,2

Název v anglickém jazyce

A new role of sigma factors in regulation of bacterial transcription

Popis výsledku anglicky

Bacterial gene expression is controlled by sigma (σ) factors, that bind to RNA polymerase (RNAP), recognize specific promoter sequences in DNA, and mediate transcription initiation. Bacteria always contain one primary or so called “housekeeping” σ factor. In the gram-positive antibiotic producing bacterium, Streptomyces coelicolor, 65 genes encoding different σ factors are found. HrdB is the main sigma factor in S. coelicolor and is responsible for expression of essential genes. On the other hand, genes that are required in different stresses or environmental conditions are regulated by alternative σ factors. Alternative σ factors are typically about half the size (~30 kDa) of HrdB and lack some of its domains. These factors recognize promoter consensus sequences different from HrdB. They are responsible for transcription of gene subsets with specific functions1,2

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů