Nickel Ferrite Nanoparticles for In Vivo Multimodal Magnetic Resonance and Magnetic Particle Imaging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F25%3A00637915" target="_blank" >RIV/61388963:_____/25:00637915 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378271:_____/25:00637915 RIV/61388971:_____/25:00637915 RIV/61389013:_____/25:00637915 RIV/00216208:11110/25:10500126 a 2 dalších

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acsanm.5c03013" target="_blank" >https://pubs.acs.org/doi/10.1021/acsanm.5c03013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsanm.5c03013" target="_blank" >10.1021/acsanm.5c03013</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nickel Ferrite Nanoparticles for In Vivo Multimodal Magnetic Resonance and Magnetic Particle Imaging

Popis výsledku v původním jazyce

Magnetic nanoparticles have been at the center of biomedical research for decades, primarily for their applications in magnetic resonance imaging (MRI) and magnetic particle imaging (MPI). Superparamagnetic particles, typically based on iron oxide crystals, are effective in both modalities, although each requires distinct magnetic properties for optimal performance. We investigated the performance of nanoparticles based on a nickel-substituted ferrite core and compared them to standard maghemite iron oxide nanoparticles. We synthesized gamma-Fe2O3 and Ni x Fe2-x O3 nanoparticles and coated them with a statistical copolymer poly(N,N-dimethylacrylamide-co-acrylic acid). In vitro testing included X-ray diffraction (XRD), Mossbauer spectroscopy, magnetometry, magnetic resonance relaxometry, magnetic particle spectroscopy, and imaging. In vivo testing involved monitoring of nanoparticle biodistribution using MPI and MRI after intracardial application in a murine model. Mossbauer spectra suggest that the Ni-substituted nanoparticles consist of a stoichiometric NiFe2O4 ferrite and a poorly crystalline antiferromagnetic iron(III) oxide-hydroxide phase. Amorphous-like impurities in Ni x Fe2-x O3 nanoparticles were probably responsible for lower saturation magnetization than that of gamma-Fe2O3 nanoparticles, as was proved by magnetometry, which led to lower r 2 relaxivity. However, MPI revealed a higher signal in the spectrum and superior imaging performance of Ni x Fe2-x O3 compared to gamma-Fe2O3 particles, likely due to shorter Neel and Brownian relaxation times. Both types of nanoparticles showed similar performance in bimodal MRI/MPI imaging in vivo. They were detected in the liver immediately after application and appeared in the spleen within 24 h. Long-term localization in the lymph nodes was also observed. Substituting an iron with a nickel ion in the core altered the magnetic properties, leading to lower saturation magnetization and an increased signal in the magnetic particle spectra, which enhanced their performance in MPI. This study demonstrates that gamma-Fe2O3 and Ni x Fe2-x O3 nanoparticles are both suitable for combined MRI/MPI imaging, magnetic particle imaging provides a highly specific signal for anatomical magnetic resonance images.

Název v anglickém jazyce

Nickel Ferrite Nanoparticles for In Vivo Multimodal Magnetic Resonance and Magnetic Particle Imaging

Popis výsledku anglicky

Magnetic nanoparticles have been at the center of biomedical research for decades, primarily for their applications in magnetic resonance imaging (MRI) and magnetic particle imaging (MPI). Superparamagnetic particles, typically based on iron oxide crystals, are effective in both modalities, although each requires distinct magnetic properties for optimal performance. We investigated the performance of nanoparticles based on a nickel-substituted ferrite core and compared them to standard maghemite iron oxide nanoparticles. We synthesized gamma-Fe2O3 and Ni x Fe2-x O3 nanoparticles and coated them with a statistical copolymer poly(N,N-dimethylacrylamide-co-acrylic acid). In vitro testing included X-ray diffraction (XRD), Mossbauer spectroscopy, magnetometry, magnetic resonance relaxometry, magnetic particle spectroscopy, and imaging. In vivo testing involved monitoring of nanoparticle biodistribution using MPI and MRI after intracardial application in a murine model. Mossbauer spectra suggest that the Ni-substituted nanoparticles consist of a stoichiometric NiFe2O4 ferrite and a poorly crystalline antiferromagnetic iron(III) oxide-hydroxide phase. Amorphous-like impurities in Ni x Fe2-x O3 nanoparticles were probably responsible for lower saturation magnetization than that of gamma-Fe2O3 nanoparticles, as was proved by magnetometry, which led to lower r 2 relaxivity. However, MPI revealed a higher signal in the spectrum and superior imaging performance of Ni x Fe2-x O3 compared to gamma-Fe2O3 particles, likely due to shorter Neel and Brownian relaxation times. Both types of nanoparticles showed similar performance in bimodal MRI/MPI imaging in vivo. They were detected in the liver immediately after application and appeared in the spleen within 24 h. Long-term localization in the lymph nodes was also observed. Substituting an iron with a nickel ion in the core altered the magnetic properties, leading to lower saturation magnetization and an increased signal in the magnetic particle spectra, which enhanced their performance in MPI. This study demonstrates that gamma-Fe2O3 and Ni x Fe2-x O3 nanoparticles are both suitable for combined MRI/MPI imaging, magnetic particle imaging provides a highly specific signal for anatomical magnetic resonance images.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Applied Nano Materials

ISSN

2574-0970

e-ISSN

2574-0970

Svazek periodika

8

Číslo periodika v rámci svazku

29

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

14867-14881

Kód UT WoS článku

001530667300001

EID výsledku v databázi Scopus

2-s2.0-105014174905