A new type of membrane raft-like microdomains and their possible involvement in TCR signaling

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F10%3A00346793" target="_blank" >RIV/61388971:_____/10:00346793 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378050:_____/10:00346793

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A new type of membrane raft-like microdomains and their possible involvement in TCR signaling

Popis výsledku v původním jazyce

One of the key signaling molecules present in T cell detergent-resistant membrane domains (DRMs) derived from membrane rafts is the transmembrane adaptor protein LAT (linker for activation of T cells). In contrast to previous results, a recent study demonstrated that a LAT construct not present in the buoyant DRMs is fully able to support TCR signaling and development of T cells in vivo. This finding caused doubts about the real physiological role of rafts in TCR signaling. In this study, we demonstratethat these results can be explained by the existence of a novel type of membrane raft-like microdomains, containing a number of membrane molecules. At a moderate level of expression, LAT supported TCR signaling more efficiently than constructs targetedto the microdomains producing heavy DRMs or to nonraft membrane. We suggest that different types of membrane microdomains provide environments regulating the functional efficiencies of signaling molecules present therein.

Název v anglickém jazyce

A new type of membrane raft-like microdomains and their possible involvement in TCR signaling

Popis výsledku anglicky

One of the key signaling molecules present in T cell detergent-resistant membrane domains (DRMs) derived from membrane rafts is the transmembrane adaptor protein LAT (linker for activation of T cells). In contrast to previous results, a recent study demonstrated that a LAT construct not present in the buoyant DRMs is fully able to support TCR signaling and development of T cells in vivo. This finding caused doubts about the real physiological role of rafts in TCR signaling. In this study, we demonstratethat these results can be explained by the existence of a novel type of membrane raft-like microdomains, containing a number of membrane molecules. At a moderate level of expression, LAT supported TCR signaling more efficiently than constructs targetedto the microdomains producing heavy DRMs or to nonraft membrane. We suggest that different types of membrane microdomains provide environments regulating the functional efficiencies of signaling molecules present therein.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Immunology

ISSN

0022-1767

e-ISSN

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Svazek periodika

184

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000275927600047

EID výsledku v databázi Scopus

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