The roles of membrane microdomains (rafts) in T cell activation.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F03%3A23033075" target="_blank" >RIV/68378050:_____/03:23033075 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The roles of membrane microdomains (rafts) in T cell activation.

Popis výsledku v původním jazyce

The conference has dealt with multiple aspects of T cell immunity, the major topic was regulatory T cells. Detergent-resistant membrane microdomains enriched in sphingolipids, cholesterol and glycosylphosphatidylinositol-anchored proteins play essentialroles in T cell receptor (TCR) signaling. These 'membrane rafts' accumulate several cytoplasmic lipid-modified molecules, including Src-family kinases, coreceptors CD4 and CD8 and transmembrane adapters LAT and PAG/Cbp, essential for either initiation oramplification of the signaling process. T cell subpopulations may differ in their use of membrane rafts. Membrane rafts are involved in many other aspects of T cell biology, such as functioning of cytokine and chemokine receptors, adhesion molecules, antigen presentation, establishing cell polarity or interaction with pathogens. Many basic raft issues, such as composition, size and heterogeneity, under native conditions, as well as the dynamics of their interactions with TCRs and other

Název v anglickém jazyce

The roles of membrane microdomains (rafts) in T cell activation.

Popis výsledku anglicky

The conference has dealt with multiple aspects of T cell immunity, the major topic was regulatory T cells. Detergent-resistant membrane microdomains enriched in sphingolipids, cholesterol and glycosylphosphatidylinositol-anchored proteins play essentialroles in T cell receptor (TCR) signaling. These 'membrane rafts' accumulate several cytoplasmic lipid-modified molecules, including Src-family kinases, coreceptors CD4 and CD8 and transmembrane adapters LAT and PAG/Cbp, essential for either initiation oramplification of the signaling process. T cell subpopulations may differ in their use of membrane rafts. Membrane rafts are involved in many other aspects of T cell biology, such as functioning of cytokine and chemokine receptors, adhesion molecules, antigen presentation, establishing cell polarity or interaction with pathogens. Many basic raft issues, such as composition, size and heterogeneity, under native conditions, as well as the dynamics of their interactions with TCRs and other

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/LN00A026" target="_blank" >LN00A026: Centrum molekulární a buněčné imunologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Immunological Reviews

ISSN

0105-2896

e-ISSN

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Svazek periodika

191

Číslo periodika v rámci svazku

N/A

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

16

Strana od-do

148-164

Kód UT WoS článku

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EID výsledku v databázi Scopus

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