Membrane microdomains in immunoreceptor signaling

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F14%3A00435782" target="_blank" >RIV/68378050:_____/14:00435782 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.febslet.2014.05.047" target="_blank" >http://dx.doi.org/10.1016/j.febslet.2014.05.047</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.febslet.2014.05.047" target="_blank" >10.1016/j.febslet.2014.05.047</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Membrane microdomains in immunoreceptor signaling

Popis výsledku v původním jazyce

Membrane microdomains denoted commonly as lipid rafts (or membrane rafts) have been implicated in T-cell receptor (TCR), and more generally immunoreceptor, signaling for over 25 years. However, this area of research has been complicated by doubts about the real nature (and even existence) of these membrane entities, especially because of methodological problems connected with possible detergent artefacts. Recent progress in biophysical approaches and functional studies of raft resident proteins apparently clarified many controversial aspects in this area. At present, the prevailing view is that these membrane microdomains are indeed involved in many aspects of cell biology, including immunoreceptor signaling. Moreover, several other types of raft-likemicrodomains (perhaps better termed nanodomains) have been described, which apparently also play important biological roles. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Název v anglickém jazyce

Membrane microdomains in immunoreceptor signaling

Popis výsledku anglicky

Membrane microdomains denoted commonly as lipid rafts (or membrane rafts) have been implicated in T-cell receptor (TCR), and more generally immunoreceptor, signaling for over 25 years. However, this area of research has been complicated by doubts about the real nature (and even existence) of these membrane entities, especially because of methodological problems connected with possible detergent artefacts. Recent progress in biophysical approaches and functional studies of raft resident proteins apparently clarified many controversial aspects in this area. At present, the prevailing view is that these membrane microdomains are indeed involved in many aspects of cell biology, including immunoreceptor signaling. Moreover, several other types of raft-likemicrodomains (perhaps better termed nanodomains) have been described, which apparently also play important biological roles. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/GBP302%2F12%2FG101" target="_blank" >GBP302/12/G101: Molekulární mechanismy signalizace receptory leukocytů - jejich role ve zdraví a nemocích.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

FEBS Letters

ISSN

0014-5793

e-ISSN

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Svazek periodika

588

Číslo periodika v rámci svazku

15

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

2392-2397

Kód UT WoS článku

000339535200006

EID výsledku v databázi Scopus

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