The Stationary-Phase Cells of Saccharomyces cerevisiae Display Dynamic Actin Filaments Required for Processes Extending Chronological Life Span
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F15%3A00455571" target="_blank" >RIV/61388971:_____/15:00455571 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1128/MCB.00811-15" target="_blank" >http://dx.doi.org/10.1128/MCB.00811-15</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/MCB.00811-15" target="_blank" >10.1128/MCB.00811-15</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The Stationary-Phase Cells of Saccharomyces cerevisiae Display Dynamic Actin Filaments Required for Processes Extending Chronological Life Span
Popis výsledku v původním jazyce
Stationary-growth-phase Saccharomyces cerevisiae yeast cultures consist of nondividing cells that undergo chronological aging. For their successful survival,the turnover of proteins and organelles, ensured by autophagy and the activation of mitochondria,is performed. Some of these processes are engaged in bythe actin cytoskeleton. In S. cerevisiae stationary-phase cells, F actin has been shown to form static aggregates named actin bodies, subsequently cited to be markers of quiescence. Our in vivo analyses revealed that stationary-phase cultures contain cells with dynamic actin filaments, besides the cells with static actin bodies. The cells with dynamic actin displayed active endocytosis and autophagy and well-developed mitochondrial networks. Even more,stationary-phase cell cultures grown under calorie restriction predominantly contained cells with actin cables, confirming that the presence of actin cables is linked to successful adaptation to stationary phase.
Název v anglickém jazyce
The Stationary-Phase Cells of Saccharomyces cerevisiae Display Dynamic Actin Filaments Required for Processes Extending Chronological Life Span
Popis výsledku anglicky
Stationary-growth-phase Saccharomyces cerevisiae yeast cultures consist of nondividing cells that undergo chronological aging. For their successful survival,the turnover of proteins and organelles, ensured by autophagy and the activation of mitochondria,is performed. Some of these processes are engaged in bythe actin cytoskeleton. In S. cerevisiae stationary-phase cells, F actin has been shown to form static aggregates named actin bodies, subsequently cited to be markers of quiescence. Our in vivo analyses revealed that stationary-phase cultures contain cells with dynamic actin filaments, besides the cells with static actin bodies. The cells with dynamic actin displayed active endocytosis and autophagy and well-developed mitochondrial networks. Even more,stationary-phase cell cultures grown under calorie restriction predominantly contained cells with actin cables, confirming that the presence of actin cables is linked to successful adaptation to stationary phase.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GAP305%2F12%2F0480" target="_blank" >GAP305/12/0480: Teplem indukované stresové granule kvasinek</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Molecular and Cellular Biology
ISSN
0270-7306
e-ISSN
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Svazek periodika
35
Číslo periodika v rámci svazku
22
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
17
Strana od-do
3892-3908
Kód UT WoS článku
000365714400008
EID výsledku v databázi Scopus
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