Microtubular and Nuclear Functions of gamma-Tubulin: Are They LINCed?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F19%3A00504271" target="_blank" >RIV/61388971:_____/19:00504271 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/2073-4409/8/3/259" target="_blank" >https://www.mdpi.com/2073-4409/8/3/259</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cells8030259" target="_blank" >10.3390/cells8030259</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Microtubular and Nuclear Functions of gamma-Tubulin: Are They LINCed?

Popis výsledku v původním jazyce

gamma-Tubulin is a conserved member of the tubulin superfamily with a function in microtubule nucleation. Proteins of gamma-tubulin complexes serve as nucleation templates as well as a majority of other proteins contributing to centrosomal and non-centrosomal nucleation, conserved across eukaryotes. There is a growing amount of evidence of gamma-tubulin functions besides microtubule nucleation in transcription, DNA damage response, chromatin remodeling, and on its interactions with tumor suppressors. However, the molecular mechanisms are not well understood. Furthermore, interactions with lamin and SUN proteins of the LINC complex suggest the role of gamma-tubulin in the coupling of nuclear organization with cytoskeletons. gamma-Tubulin that belongs to the clade of eukaryotic tubulins shows characteristics of both prokaryotic and eukaryotic tubulins. Both human and plant gamma-tubulins preserve the ability of prokaryotic tubulins to assemble filaments and higher-order fibrillar networks. gamma-Tubulin filaments, with bundling and aggregating capacity, are suggested to perform complex scaffolding and sequestration functions. In this review, we discuss a plethora of gamma-tubulin molecular interactions and cellular functions, as well as recent advances in understanding the molecular mechanisms behind them.

Název v anglickém jazyce

Microtubular and Nuclear Functions of gamma-Tubulin: Are They LINCed?

Popis výsledku anglicky

gamma-Tubulin is a conserved member of the tubulin superfamily with a function in microtubule nucleation. Proteins of gamma-tubulin complexes serve as nucleation templates as well as a majority of other proteins contributing to centrosomal and non-centrosomal nucleation, conserved across eukaryotes. There is a growing amount of evidence of gamma-tubulin functions besides microtubule nucleation in transcription, DNA damage response, chromatin remodeling, and on its interactions with tumor suppressors. However, the molecular mechanisms are not well understood. Furthermore, interactions with lamin and SUN proteins of the LINC complex suggest the role of gamma-tubulin in the coupling of nuclear organization with cytoskeletons. gamma-Tubulin that belongs to the clade of eukaryotic tubulins shows characteristics of both prokaryotic and eukaryotic tubulins. Both human and plant gamma-tubulins preserve the ability of prokaryotic tubulins to assemble filaments and higher-order fibrillar networks. gamma-Tubulin filaments, with bundling and aggregating capacity, are suggested to perform complex scaffolding and sequestration functions. In this review, we discuss a plethora of gamma-tubulin molecular interactions and cellular functions, as well as recent advances in understanding the molecular mechanisms behind them.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

<a href="/cs/project/GA15-11657S" target="_blank" >GA15-11657S: Úloha gama- tubulinu v koordinaci nukleace mikrotubulů a buněčného dělení s odpovědí buňky na poškození DNA u rostlin</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cells

ISSN

2073-4409

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

17

Strana od-do

259

Kód UT WoS článku

000464194500002

EID výsledku v databázi Scopus

2-s2.0-85042859952