Experimental in vitro dosimetry of 223Ra and 177Lu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F22%3A00560657" target="_blank" >RIV/61389005:_____/22:00560657 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21340/22:00359544

Výsledek na webu

<a href="https://doi.org/10.1093/rpd/ncac090" target="_blank" >https://doi.org/10.1093/rpd/ncac090</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/rpd/ncac090" target="_blank" >10.1093/rpd/ncac090</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Experimental in vitro dosimetry of 223Ra and 177Lu

Popis výsledku v původním jazyce

Targeted alpha therapy with radionuclides undergoing multiple alpha-particle decays is a promising method of nuclear medicine. To study the effectiveness of alpha versus beta emitters, survival of DU145 prostate cancer cells exposed to Ra-223 or Lu-177 was assessed. Per decay, the cells were much more sensitive to the alpha than beta emitter. However, per unit dose the sensitivities would be comparable, contrary to the well-known evidence, if the decay energy were deposited within the sample completely and homogeneously. Measurements by Timepix detectors showed about three times higher counts of alpha particles above than below the sample. After the first alpha decay of Ra-223 to Rn-219, this gas likely moves upwards and its subsequent three alpha decays occur in the upper part of the sample. Correct estimation of absorbed dose is a critical issue when analysing in vitro data and when translating their results to clinical applications.

Název v anglickém jazyce

Experimental in vitro dosimetry of 223Ra and 177Lu

Popis výsledku anglicky

Targeted alpha therapy with radionuclides undergoing multiple alpha-particle decays is a promising method of nuclear medicine. To study the effectiveness of alpha versus beta emitters, survival of DU145 prostate cancer cells exposed to Ra-223 or Lu-177 was assessed. Per decay, the cells were much more sensitive to the alpha than beta emitter. However, per unit dose the sensitivities would be comparable, contrary to the well-known evidence, if the decay energy were deposited within the sample completely and homogeneously. Measurements by Timepix detectors showed about three times higher counts of alpha particles above than below the sample. After the first alpha decay of Ra-223 to Rn-219, this gas likely moves upwards and its subsequent three alpha decays occur in the upper part of the sample. Correct estimation of absorbed dose is a critical issue when analysing in vitro data and when translating their results to clinical applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/TJ04000129" target="_blank" >TJ04000129: Separace radionuklidů pro cílenou alfa částicovou terapii</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Radiation Protection Dosimetry

ISSN

0144-8420

e-ISSN

1742-3406

Svazek periodika

198

Číslo periodika v rámci svazku

9-11

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

508-513

Kód UT WoS článku

000844405700003

EID výsledku v databázi Scopus

2-s2.0-85160102787