Colloidally stable surface-modified iron oxide nanoparticles: preparation, characterization and anti-tumor activity
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F15%3A00442140" target="_blank" >RIV/61389013:_____/15:00442140 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.jmmm.2014.09.037" target="_blank" >http://dx.doi.org/10.1016/j.jmmm.2014.09.037</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jmmm.2014.09.037" target="_blank" >10.1016/j.jmmm.2014.09.037</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Colloidally stable surface-modified iron oxide nanoparticles: preparation, characterization and anti-tumor activity
Popis výsledku v původním jazyce
Maghemite (?-Fe2O3) nanoparticles were obtained by co-precipitation of Fe(II) and Fe(III) chlorides and subsequent oxidation with sodium hypochlorite and coated with poly(N,N-dimethylacrylamide-co-acrylic acid) [P(DMAAm-AA)]. They were characterized by arange of methods including transmission electron microscopy (TEM), elemental analysis, dynamic light scattering (DLS) and zeta potential measurements. The effect of superparamagnetic P(DMAAm-AA)-?-Fe2O3 nanoparticles on oxidation of blood lipids, glutathione and proteins in blood serum was detected using 2-thiobarbituric acid and the ThioGlo fluorophore. Finally, mice received magnetic nanoparticles administered per os and the antitumor activity of the particles was tested on Lewis lung carcinoma (LLC)in male mice line ?57?L/6 as an experimental in vivo metastatic tumor model; the tumor size was measured and the number of metastases in lungs was determined. Surface-modified ?-Fe2O3 nanoparticles showed higher antitumor and antimetasta
Název v anglickém jazyce
Colloidally stable surface-modified iron oxide nanoparticles: preparation, characterization and anti-tumor activity
Popis výsledku anglicky
Maghemite (?-Fe2O3) nanoparticles were obtained by co-precipitation of Fe(II) and Fe(III) chlorides and subsequent oxidation with sodium hypochlorite and coated with poly(N,N-dimethylacrylamide-co-acrylic acid) [P(DMAAm-AA)]. They were characterized by arange of methods including transmission electron microscopy (TEM), elemental analysis, dynamic light scattering (DLS) and zeta potential measurements. The effect of superparamagnetic P(DMAAm-AA)-?-Fe2O3 nanoparticles on oxidation of blood lipids, glutathione and proteins in blood serum was detected using 2-thiobarbituric acid and the ThioGlo fluorophore. Finally, mice received magnetic nanoparticles administered per os and the antitumor activity of the particles was tested on Lewis lung carcinoma (LLC)in male mice line ?57?L/6 as an experimental in vivo metastatic tumor model; the tumor size was measured and the number of metastases in lungs was determined. Surface-modified ?-Fe2O3 nanoparticles showed higher antitumor and antimetasta
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CD - Makromolekulární chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Magnetism and Magnetic Materials
ISSN
0304-8853
e-ISSN
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Svazek periodika
380
Číslo periodika v rámci svazku
15 April
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
7
Strana od-do
125-131
Kód UT WoS článku
000349360800021
EID výsledku v databázi Scopus
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