Synthesis and solution properties of PCL-b-PHPMA diblock copolymers containing stable nitroxyl radicals

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F16%3A00462673" target="_blank" >RIV/61389013:_____/16:00462673 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/16:10327751

Výsledek na webu

<a href="http://dx.doi.org/10.1021/acs.macromol.6b01187" target="_blank" >http://dx.doi.org/10.1021/acs.macromol.6b01187</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.macromol.6b01187" target="_blank" >10.1021/acs.macromol.6b01187</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis and solution properties of PCL-b-PHPMA diblock copolymers containing stable nitroxyl radicals

Popis výsledku v původním jazyce

This work focuses on the synthesis and the aqueous solution properties of novel amphiphilic PCL-b-PHPMA diblock copolymers possessing 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) stable radicals covalently conjugated to the hydrophobic poly(ε-caprolactone) (PCL) block. A new synthetic approach (a four-step pathway) combining ring-opening polymerization (ROP), carbodiimide chemistry (DCC method), a reversible addition–fragmentation chain transfer (RAFT) polymerization technique, and finally chemical oxidation was employed to successfully produce a series of TEMPO-containing PCL-b-PHPMA diblock copolymers for the first time. EPR spectroscopy was applied to verify successful oxidation of the synthesized diblock copolymers and to investigate the dynamics of the polymer chains before and after micellization. The diblock copolymers self-assembled in PBS solution into spherical radical-containing nanoparticles (RNPs), which were characterized by 1H NMR spectroscopy, dynamic (DLS), static (SLS) light scattering, and cryo-transmission electron microscopy (cryo-TEM). These novel RNPs could find applications, e.g., as drug delivery systems and for the treatment of oxidative stress injuries.

Název v anglickém jazyce

Synthesis and solution properties of PCL-b-PHPMA diblock copolymers containing stable nitroxyl radicals

Popis výsledku anglicky

This work focuses on the synthesis and the aqueous solution properties of novel amphiphilic PCL-b-PHPMA diblock copolymers possessing 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) stable radicals covalently conjugated to the hydrophobic poly(ε-caprolactone) (PCL) block. A new synthetic approach (a four-step pathway) combining ring-opening polymerization (ROP), carbodiimide chemistry (DCC method), a reversible addition–fragmentation chain transfer (RAFT) polymerization technique, and finally chemical oxidation was employed to successfully produce a series of TEMPO-containing PCL-b-PHPMA diblock copolymers for the first time. EPR spectroscopy was applied to verify successful oxidation of the synthesized diblock copolymers and to investigate the dynamics of the polymer chains before and after micellization. The diblock copolymers self-assembled in PBS solution into spherical radical-containing nanoparticles (RNPs), which were characterized by 1H NMR spectroscopy, dynamic (DLS), static (SLS) light scattering, and cryo-transmission electron microscopy (cryo-TEM). These novel RNPs could find applications, e.g., as drug delivery systems and for the treatment of oxidative stress injuries.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Macromolecules

ISSN

0024-9297

e-ISSN

—

Svazek periodika

49

Číslo periodika v rámci svazku

15

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

5407-5417

Kód UT WoS článku

000381320300012

EID výsledku v databázi Scopus

2-s2.0-84981164968