The effect of ionizing radiation on biocompatible polymers: From sterilization to radiolysis and hydrogel formation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F17%3A00469647" target="_blank" >RIV/61389013:_____/17:00469647 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.polymdegradstab.2017.01.005" target="_blank" >http://dx.doi.org/10.1016/j.polymdegradstab.2017.01.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.polymdegradstab.2017.01.005" target="_blank" >10.1016/j.polymdegradstab.2017.01.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The effect of ionizing radiation on biocompatible polymers: From sterilization to radiolysis and hydrogel formation

Popis výsledku v původním jazyce

The sensitivity of biocompatible polymers to ionizing radiation plays a crucial role for the construction of polymer radiopharmaceutics, simultaneous radiotherapy and therapy with polymeric drugs, and the radiation sterilization of polymer samples. Herein, we answer the crucial but generally overlooked question of radiation stability of water-soluble biocompatible polymers that are used in designing of polymer radiotherapeutics. We ranked five different classes of widely used water-soluble polymers according to their sensitivity to the beta or gamma radiation, providing the guidelines for selection of appropriate polymers that will be in contact with radiation. As a result, poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) and poly(N-vinyl-2-pyrrolidone) (PVP) proved to be more resistant against ionizing radiation than poly(ethylene oxide) (PEO) or poly(2-ethyl-2-oxazoline) (PEtOx), which were crosslinked rapidly. Nevertheless, irradiation of PEtOx and PEO homopolymers appeared to be a fast and straightforward route to their respective hydrogels. Special emphasis was put on the beta radiation preparation of PEtOx hydrogels, which was never described before. Irradiation of poly(N-isopropyl acrylamide) (PNIPAM) in solution leads to its hydrophilization and an increase in its cloud point temperature.

Název v anglickém jazyce

The effect of ionizing radiation on biocompatible polymers: From sterilization to radiolysis and hydrogel formation

Popis výsledku anglicky

The sensitivity of biocompatible polymers to ionizing radiation plays a crucial role for the construction of polymer radiopharmaceutics, simultaneous radiotherapy and therapy with polymeric drugs, and the radiation sterilization of polymer samples. Herein, we answer the crucial but generally overlooked question of radiation stability of water-soluble biocompatible polymers that are used in designing of polymer radiotherapeutics. We ranked five different classes of widely used water-soluble polymers according to their sensitivity to the beta or gamma radiation, providing the guidelines for selection of appropriate polymers that will be in contact with radiation. As a result, poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) and poly(N-vinyl-2-pyrrolidone) (PVP) proved to be more resistant against ionizing radiation than poly(ethylene oxide) (PEO) or poly(2-ethyl-2-oxazoline) (PEtOx), which were crosslinked rapidly. Nevertheless, irradiation of PEtOx and PEO homopolymers appeared to be a fast and straightforward route to their respective hydrogels. Special emphasis was put on the beta radiation preparation of PEtOx hydrogels, which was never described before. Irradiation of poly(N-isopropyl acrylamide) (PNIPAM) in solution leads to its hydrophilization and an increase in its cloud point temperature.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Polymer Degradation and Stability

ISSN

0141-3910

e-ISSN

—

Svazek periodika

137

Číslo periodika v rámci svazku

March

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

1-10

Kód UT WoS článku

000396948100001

EID výsledku v databázi Scopus

2-s2.0-85009355997