Effect of Fe3O4@SiO2 nanoparticle diameter on glutamate transport in brain nerve terminals

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F19%3A00502417" target="_blank" >RIV/61389013:_____/19:00502417 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.ingentaconnect.com/content/asp/nnl/2019/00000011/00000001/art00008" target="_blank" >https://www.ingentaconnect.com/content/asp/nnl/2019/00000011/00000001/art00008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1166/nnl.2019.2853" target="_blank" >10.1166/nnl.2019.2853</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of Fe3O4@SiO2 nanoparticle diameter on glutamate transport in brain nerve terminals

Popis výsledku v původním jazyce

Monodispersed silica-coated magnetite nanoparticles (Fe3O4 @ SiO2) with diameters of 11, 20, and 24 nm were synthesized by thermal decomposition, hydrolysis and condensation of tetramethyl orthosilicate. Substantial Fe3O4 @ SiO2 particle size effects on glutamate transport in brain nerve terminals were observed. The balance between tonic release and uptake of glutamate affects the extracellular glutamate concentration and physiological synaptic neurotransmission. A smaller particle diameter (11 nm) resulted in a greater extracellular concentration and tonic release of L-[14C]-glutamate in rat synaptosomes. However, lower L-[14C]-glutamate uptake and synaptic vesicle acidification was observed with larger particles (20 and 24 nm). The neuromodulatory effect of the Fe3O4 @ SiO2 nanoparticles in synaptosomes was considerably increased by decreasing the particle diameter from 24 to 11 nm. The particle diameter was determined to be a critical parameter, and the manipulation of this parameter could be used to control the effect of the nanoparticles in biotechnological and medical applications.

Název v anglickém jazyce

Effect of Fe3O4@SiO2 nanoparticle diameter on glutamate transport in brain nerve terminals

Popis výsledku anglicky

Monodispersed silica-coated magnetite nanoparticles (Fe3O4 @ SiO2) with diameters of 11, 20, and 24 nm were synthesized by thermal decomposition, hydrolysis and condensation of tetramethyl orthosilicate. Substantial Fe3O4 @ SiO2 particle size effects on glutamate transport in brain nerve terminals were observed. The balance between tonic release and uptake of glutamate affects the extracellular glutamate concentration and physiological synaptic neurotransmission. A smaller particle diameter (11 nm) resulted in a greater extracellular concentration and tonic release of L-[14C]-glutamate in rat synaptosomes. However, lower L-[14C]-glutamate uptake and synaptic vesicle acidification was observed with larger particles (20 and 24 nm). The neuromodulatory effect of the Fe3O4 @ SiO2 nanoparticles in synaptosomes was considerably increased by decreasing the particle diameter from 24 to 11 nm. The particle diameter was determined to be a critical parameter, and the manipulation of this parameter could be used to control the effect of the nanoparticles in biotechnological and medical applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nanoscience and Nanotechnology Letters

ISSN

1941-4900

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

61-69

Kód UT WoS článku

000459175700008

EID výsledku v databázi Scopus

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