Development of novel nanoparticles for MPI

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F20%3A00535233" target="_blank" >RIV/61389013:_____/20:00535233 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378271:_____/20:00535233 RIV/00216208:11110/20:10419944

Výsledek na webu

<a href="https://journal.iwmpi.org/index.php/iwmpi/article/view/303" target="_blank" >https://journal.iwmpi.org/index.php/iwmpi/article/view/303</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.18416/IJMPI.2020.2009019" target="_blank" >10.18416/IJMPI.2020.2009019</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Development of novel nanoparticles for MPI

Popis výsledku v původním jazyce

A modified procedure for preparation of iron oxide nanoparticles was used to produce nanoparticles suitable for magnetic particle imaging (MPI). Cationic and anionic maghemite particles were prepared and coated by poly(N-(2-hydroxypropyl)methacrylamide)-co-N-[2-(hydroxyamino)-2-oxo-ethyl]-2-methyl-prop-2-enamide. Bare and coated particles were characterized by magnetometry, dynamic light scattering, MR relaxometry, transmission electron microscopy and tested in vitro in a field-free-point MPI scanner. The nanoparticles were compared to Resovist and to differently oxidized particles dedicated for magnetic resonance imaging (control NP). The cores of particles had an average diameter 8.0 nm (cationic ones) and 8.7 nm (anionic ones), hydrodynamic diameter of coated particles in water colloids was 88 nm, and zeta potential +52 mV or –60 mV for cationic or anionic particles respectively). Cationic particles provided at MPI lower signal-to-noise ratio than Resovist, while anionic higher by 25%. Also signal dispersion to surrounding voxel was smaller. The worst results were reached in the case of control NP.

Název v anglickém jazyce

Development of novel nanoparticles for MPI

Popis výsledku anglicky

A modified procedure for preparation of iron oxide nanoparticles was used to produce nanoparticles suitable for magnetic particle imaging (MPI). Cationic and anionic maghemite particles were prepared and coated by poly(N-(2-hydroxypropyl)methacrylamide)-co-N-[2-(hydroxyamino)-2-oxo-ethyl]-2-methyl-prop-2-enamide. Bare and coated particles were characterized by magnetometry, dynamic light scattering, MR relaxometry, transmission electron microscopy and tested in vitro in a field-free-point MPI scanner. The nanoparticles were compared to Resovist and to differently oxidized particles dedicated for magnetic resonance imaging (control NP). The cores of particles had an average diameter 8.0 nm (cationic ones) and 8.7 nm (anionic ones), hydrodynamic diameter of coated particles in water colloids was 88 nm, and zeta potential +52 mV or –60 mV for cationic or anionic particles respectively). Cationic particles provided at MPI lower signal-to-noise ratio than Resovist, while anionic higher by 25%. Also signal dispersion to surrounding voxel was smaller. The worst results were reached in the case of control NP.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal on Magnetic Particle Imaging

ISSN

2365-9033

e-ISSN

—

Svazek periodika

6

Číslo periodika v rámci svazku

2 Suppl. 1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

3

Strana od-do

1-3

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85090281088