Zwitterionic polyaspartamides based on L-lysine side-chain moieties: synthesis, nonfouling properties and direct/indirect nanogel preparation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00540931" target="_blank" >RIV/61389013:_____/21:00540931 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/21:10430571

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0014305721000811?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0014305721000811?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.eurpolymj.2021.110347" target="_blank" >10.1016/j.eurpolymj.2021.110347</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Zwitterionic polyaspartamides based on L-lysine side-chain moieties: synthesis, nonfouling properties and direct/indirect nanogel preparation

Popis výsledku v původním jazyce

The ability of polysuccinimide (PSI) to open the succinimide ring by nucleophilic reagents leads to the formation of various polyaspartamides under mild conditions. In the current work, amino acids, such as Nα-Boc-L-lysine, leading to the formation of exclusively α-substituted L-lysine polypeptides and L-lysine methyl ester were used as the ring-opening reagents for PSI. The formed materials possess both positively and negatively charged groups on the same repeat unit simultaneously serving as zwitterionic moieties. The chemical structure and component composition were confirmed by 1H NMR and UV/vis spectroscopies. Zwitterionic properties of the synthesized polymers were investigated by zeta potential measurements. The obtained zwitterionic polyaspartamides exhibited anti-protein adsorption properties and the ability to create hydrophilic surfaces. The zwitterionic polyaspartamide nanogels obtained by horseradish peroxidase-mediated crosslinking in inverse miniemulsions and applying different preparation strategies were analysed by dynamic light scattering (DLS) measurements and transmission electron microscopy (TEM) analysis. The results indicated the good morphology and architecture of the nanogels. These peptide-based zwitterionic nanogels, due to their good biocompatibility and anti-protein adsorption ability, are promising materials for biomedical applications.

Název v anglickém jazyce

Zwitterionic polyaspartamides based on L-lysine side-chain moieties: synthesis, nonfouling properties and direct/indirect nanogel preparation

Popis výsledku anglicky

The ability of polysuccinimide (PSI) to open the succinimide ring by nucleophilic reagents leads to the formation of various polyaspartamides under mild conditions. In the current work, amino acids, such as Nα-Boc-L-lysine, leading to the formation of exclusively α-substituted L-lysine polypeptides and L-lysine methyl ester were used as the ring-opening reagents for PSI. The formed materials possess both positively and negatively charged groups on the same repeat unit simultaneously serving as zwitterionic moieties. The chemical structure and component composition were confirmed by 1H NMR and UV/vis spectroscopies. Zwitterionic properties of the synthesized polymers were investigated by zeta potential measurements. The obtained zwitterionic polyaspartamides exhibited anti-protein adsorption properties and the ability to create hydrophilic surfaces. The zwitterionic polyaspartamide nanogels obtained by horseradish peroxidase-mediated crosslinking in inverse miniemulsions and applying different preparation strategies were analysed by dynamic light scattering (DLS) measurements and transmission electron microscopy (TEM) analysis. The results indicated the good morphology and architecture of the nanogels. These peptide-based zwitterionic nanogels, due to their good biocompatibility and anti-protein adsorption ability, are promising materials for biomedical applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

<a href="/cs/project/GA18-03224S" target="_blank" >GA18-03224S: INJIKOVATELNÉ HYDROGELY NA BÁZI POLYPEPTIDŮ NAPODOBUJÍCÍ DYNAMICKÉ PROCESY MEZIBUNĚČNÉ HMOTY</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Polymer Journal

ISSN

0014-3057

e-ISSN

1873-1945

Svazek periodika

148

Číslo periodika v rámci svazku

5 April

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

110347

Kód UT WoS článku

000639291300002

EID výsledku v databázi Scopus

2-s2.0-85101500212