Synthesis and anti-fouling properties of zwitterionic poly(L-glutamic acid)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00573142" target="_blank" >RIV/61389013:_____/23:00573142 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s13233-023-00145-6" target="_blank" >https://link.springer.com/article/10.1007/s13233-023-00145-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s13233-023-00145-6" target="_blank" >10.1007/s13233-023-00145-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis and anti-fouling properties of zwitterionic poly(L-glutamic acid)

Popis výsledku v původním jazyce

Zwitterionic polymers are frequently used as non-fouling materials for surface modification with following application in medical devices, implants or areas of our lives such as food, water, and energy. Here, authors report the synthesis of zwitterionic poly(l-glutamic acid) copolymer bearing sulfobetaine via combining the ring-opening polymerization of N-carboxyanhydride of γ-benzyl-l-glutamate and grafting reaction of propargylamine, tyramine, and 3-(dimethylamino)-1-propylamine to the polymer backbone with subsequent reaction of 1,3-propanesultone leading to the formation of zwitterionic poly(l-glutamic acid) containing sulfobetaine groups. Zwitterionic properties of the copolymer are represented by positively charged quaternary ammonium groups and negatively charged sulfobetaine moieties. The chemical structure of the synthesized zwitterionic poly(l-glutamic acid) was characterized by 1H NMR, FTIR, and UV/Vis spectroscopy. The zwitterionic abilities of copolymer were confirmed by zeta potential measurements. The zeta potential of zwitterionic polymer decreased from + 15 mV to − 19 mV upon stepwise pH increases from 2 to 11. The surface properties such as hydrophilicity and non-fouling abilities were tested by contact angle analysis and surface plasmon resonance technique, respectively. The prepared material indicates the formation of highly hydrophilic surfaces with relatively low contact angle (26°) and remarkable anti-protein adsorption functions reflected in lower resonance wavelength shifts from SPR sensogram. Results of this work show the importance of the developed biodegradable zwitterionic poly(l-glutamic acid)-based coatings for applications in various biomedical fields.

Název v anglickém jazyce

Synthesis and anti-fouling properties of zwitterionic poly(L-glutamic acid)

Popis výsledku anglicky

Zwitterionic polymers are frequently used as non-fouling materials for surface modification with following application in medical devices, implants or areas of our lives such as food, water, and energy. Here, authors report the synthesis of zwitterionic poly(l-glutamic acid) copolymer bearing sulfobetaine via combining the ring-opening polymerization of N-carboxyanhydride of γ-benzyl-l-glutamate and grafting reaction of propargylamine, tyramine, and 3-(dimethylamino)-1-propylamine to the polymer backbone with subsequent reaction of 1,3-propanesultone leading to the formation of zwitterionic poly(l-glutamic acid) containing sulfobetaine groups. Zwitterionic properties of the copolymer are represented by positively charged quaternary ammonium groups and negatively charged sulfobetaine moieties. The chemical structure of the synthesized zwitterionic poly(l-glutamic acid) was characterized by 1H NMR, FTIR, and UV/Vis spectroscopy. The zwitterionic abilities of copolymer were confirmed by zeta potential measurements. The zeta potential of zwitterionic polymer decreased from + 15 mV to − 19 mV upon stepwise pH increases from 2 to 11. The surface properties such as hydrophilicity and non-fouling abilities were tested by contact angle analysis and surface plasmon resonance technique, respectively. The prepared material indicates the formation of highly hydrophilic surfaces with relatively low contact angle (26°) and remarkable anti-protein adsorption functions reflected in lower resonance wavelength shifts from SPR sensogram. Results of this work show the importance of the developed biodegradable zwitterionic poly(l-glutamic acid)-based coatings for applications in various biomedical fields.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/GA21-06524S" target="_blank" >GA21-06524S: Xeno-free enzymaticky degradovatelné polymerní materiály pro 4D biotisk</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Macromolecular Research

ISSN

1598-5032

e-ISSN

2092-7673

Svazek periodika

31

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

KR - Korejská republika

Počet stran výsledku

9

Strana od-do

593-601

Kód UT WoS článku

000944096700001

EID výsledku v databázi Scopus

2-s2.0-85149290139