Comparison of carboxybetaine with sulfobetaine polyaspartamides: Nonfouling properties, hydrophilicity, cytotoxicity and model nanogelation in an inverse miniemulsion

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00555583" target="_blank" >RIV/61389013:_____/22:00555583 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/22:10446618

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/app.52099" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/app.52099</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/app.52099" target="_blank" >10.1002/app.52099</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of carboxybetaine with sulfobetaine polyaspartamides: Nonfouling properties, hydrophilicity, cytotoxicity and model nanogelation in an inverse miniemulsion

Popis výsledku v původním jazyce

Zwitterionic polymers are promising non-fouling materials widely used for surface modification. Here, we report the synthesis of zwitterionic polyaspartamides bearing carboxybetaine and sulfobetaine prepared via combining the ring-opening reaction of polysuccinimide with 3-(dimethylamino)-1-propylamine and the reaction of the formed tertiary amine side groups with 1,3-propanesultone and 4-bromobutyric acid, respectively. Both sulfobetaine and carboxybetaine polyaspartamides have cationic and anionic charged groups on the same repeat unit, but they differ in negatively charged groups. The chemical structures of the synthesized polymers were confirmed by 1H NMR and FT-IR spectroscopies. The zwitterionic property of polyaspartamides were characterized by zeta potential measurements using wide range of pH. The surface properties mainly anti-protein adsorption abilities and hydrophilicity were tested by surface plasmon resonance analysis, fluorescence microscopy, and contact angle measurements. Importantly, sulfobetaine polyaspartamides demonstrated better both antifouling performance and ability to form more hydrophilic surfaces than carboxybetaine polyaspartamide. Two zwitterionic carboxybetaine and sulfobetaine nanogels were prepared by horseradish peroxidase-mediated crosslinking in an inverse miniemulsion. Results from dynamic light scattering and transmission electron microscopy showed the formation of nanosized spherical particles. Additionally, sulfobetaine and carboxybetaine polyaspartamides had remarkable biocompatibilities, indicating their promise as non-fouling materials for biomedical applications.

Název v anglickém jazyce

Comparison of carboxybetaine with sulfobetaine polyaspartamides: Nonfouling properties, hydrophilicity, cytotoxicity and model nanogelation in an inverse miniemulsion

Popis výsledku anglicky

Zwitterionic polymers are promising non-fouling materials widely used for surface modification. Here, we report the synthesis of zwitterionic polyaspartamides bearing carboxybetaine and sulfobetaine prepared via combining the ring-opening reaction of polysuccinimide with 3-(dimethylamino)-1-propylamine and the reaction of the formed tertiary amine side groups with 1,3-propanesultone and 4-bromobutyric acid, respectively. Both sulfobetaine and carboxybetaine polyaspartamides have cationic and anionic charged groups on the same repeat unit, but they differ in negatively charged groups. The chemical structures of the synthesized polymers were confirmed by 1H NMR and FT-IR spectroscopies. The zwitterionic property of polyaspartamides were characterized by zeta potential measurements using wide range of pH. The surface properties mainly anti-protein adsorption abilities and hydrophilicity were tested by surface plasmon resonance analysis, fluorescence microscopy, and contact angle measurements. Importantly, sulfobetaine polyaspartamides demonstrated better both antifouling performance and ability to form more hydrophilic surfaces than carboxybetaine polyaspartamide. Two zwitterionic carboxybetaine and sulfobetaine nanogels were prepared by horseradish peroxidase-mediated crosslinking in an inverse miniemulsion. Results from dynamic light scattering and transmission electron microscopy showed the formation of nanosized spherical particles. Additionally, sulfobetaine and carboxybetaine polyaspartamides had remarkable biocompatibilities, indicating their promise as non-fouling materials for biomedical applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/GA21-06524S" target="_blank" >GA21-06524S: Xeno-free enzymaticky degradovatelné polymerní materiály pro 4D biotisk</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Polymer Science

ISSN

0021-8995

e-ISSN

1097-4628

Svazek periodika

139

Číslo periodika v rámci svazku

19

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

e52099

Kód UT WoS článku

000736089600001

EID výsledku v databázi Scopus

2-s2.0-85122062038