2-Hydroxyethyl methacrylate hydrogels for local drug delivery: study of topotecan and vincristine sorption/desorption kinetics and polymer-drug interaction by ATR-FTIR spectroscopy
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00543672" target="_blank" >RIV/61389013:_____/21:00543672 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064203:_____/21:10427616 RIV/00216208:11130/21:10427616
Výsledek na webu
<a href="https://onlinelibrary.wiley.com/doi/10.1002/macp.202100086" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/macp.202100086</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/macp.202100086" target="_blank" >10.1002/macp.202100086</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
2-Hydroxyethyl methacrylate hydrogels for local drug delivery: study of topotecan and vincristine sorption/desorption kinetics and polymer-drug interaction by ATR-FTIR spectroscopy
Popis výsledku v původním jazyce
Poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogels are well known in ophthalmological applications and recently investigated as drug delivery systems. The study represents a theoretical approach where the sorption/desorption experiments and spectroscopic study is used to describe the influence of the pHEMA network structure on the sorption capacity and mechanism of the release of topotecan (TPT) and vincristine (VCR). The hydrogels are synthesized by free-radical crosslinking polymerization of HEMA monomer with ethylene glycol dimethacrylate as a crosslinker in the concentration range from 0.3 to 1 wt%. Experimental data from sorption kinetics are evaluated using sorption kinetic models and sorption isotherms, drug release mechanism is assessed by two different models and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy is employed to describe the polymer-drug interaction. pHEMA hydrogels exhibit higher affinity for TPT than for VCR and hydrogels prepared with 0.5 wt% of crosslinker show the maximum sorption capacity for both drugs. Physisorption is proved to be the sorption mechanism. Analyzing the FTIR spectra, it is concluded that the hydrophobic crosslinks play an important role in the interaction of the hydrogel backbone with molecules of both drugs.
Název v anglickém jazyce
2-Hydroxyethyl methacrylate hydrogels for local drug delivery: study of topotecan and vincristine sorption/desorption kinetics and polymer-drug interaction by ATR-FTIR spectroscopy
Popis výsledku anglicky
Poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogels are well known in ophthalmological applications and recently investigated as drug delivery systems. The study represents a theoretical approach where the sorption/desorption experiments and spectroscopic study is used to describe the influence of the pHEMA network structure on the sorption capacity and mechanism of the release of topotecan (TPT) and vincristine (VCR). The hydrogels are synthesized by free-radical crosslinking polymerization of HEMA monomer with ethylene glycol dimethacrylate as a crosslinker in the concentration range from 0.3 to 1 wt%. Experimental data from sorption kinetics are evaluated using sorption kinetic models and sorption isotherms, drug release mechanism is assessed by two different models and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy is employed to describe the polymer-drug interaction. pHEMA hydrogels exhibit higher affinity for TPT than for VCR and hydrogels prepared with 0.5 wt% of crosslinker show the maximum sorption capacity for both drugs. Physisorption is proved to be the sorption mechanism. Analyzing the FTIR spectra, it is concluded that the hydrophobic crosslinks play an important role in the interaction of the hydrogel backbone with molecules of both drugs.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10404 - Polymer science
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Macromolecular Chemistry and Physics
ISSN
1022-1352
e-ISSN
1521-3935
Svazek periodika
222
Číslo periodika v rámci svazku
13
Stát vydavatele periodika
DE - Spolková republika Německo
Počet stran výsledku
11
Strana od-do
2100086
Kód UT WoS článku
000646753700001
EID výsledku v databázi Scopus
2-s2.0-85105077530