Well-defined poly(HPMAm) brushes via surface-initiated RAFT polymerization, a mixed-chain transfer agent (CTA) approach

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00637489" target="_blank" >RIV/61389013:_____/25:00637489 - isvavai.cz</a>

Výsledek na webu

<a href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/admi.202500196" target="_blank" >https://advanced.onlinelibrary.wiley.com/doi/10.1002/admi.202500196</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/admi.202500196" target="_blank" >10.1002/admi.202500196</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Well-defined poly(HPMAm) brushes via surface-initiated RAFT polymerization, a mixed-chain transfer agent (CTA) approach

Popis výsledku v původním jazyce

Over three decades, efforts to prevent non-specific protein adsorption on surfaces have improved. However, developing well-defined antifouling coatings remains a challenge in biomaterials research. In this study, a rapid and straightforward protocol relying on surface-initiated reversible addition-fragmentation chain-transfer (RAFT) polymerization (S-RAFT) is demonstrated to fabricate poly(N-(2-hydroxypropyl methacrylamide), poly(HPMAm)) brushes employing a mixed-chain transfer agent (CTA) approach. By systematically evaluating different combinations of surface-tethered and free CTAs, it is demonstrated that the simultaneous use of structurally distinct CTA classes, dithiobenzoate (DTB) and trithiocarbonate (TTC), enhances polymerization control and brush growth rates. The conditions enable the fabrication of poly(HPMAm) brushes exceeding 70 nm in thickness within only 4 h at 50 °C. Spectroscopic ellipsometry confirmed that the mixed-CTA approach significantly outperforms single-CTA systems, yielding higher polymerization efficiency and greater brush thickness. Additionally, size exclusion chromatography (SEC) confirmed that the solution-born polymers exhibited narrow dispersity (Ð = 1.05–1.15), ensuring well-defined polymer structures. The findings highlight the advantages of combining different CTAs in a single polymerization system, leading to a more efficient and scalable method for fabricating antifouling poly(HPMAm) coatings. This approach offers a significant potential for biomedical applications, including biosensors, blood-contacting devices, and implantable materials.

Název v anglickém jazyce

Well-defined poly(HPMAm) brushes via surface-initiated RAFT polymerization, a mixed-chain transfer agent (CTA) approach

Popis výsledku anglicky

Over three decades, efforts to prevent non-specific protein adsorption on surfaces have improved. However, developing well-defined antifouling coatings remains a challenge in biomaterials research. In this study, a rapid and straightforward protocol relying on surface-initiated reversible addition-fragmentation chain-transfer (RAFT) polymerization (S-RAFT) is demonstrated to fabricate poly(N-(2-hydroxypropyl methacrylamide), poly(HPMAm)) brushes employing a mixed-chain transfer agent (CTA) approach. By systematically evaluating different combinations of surface-tethered and free CTAs, it is demonstrated that the simultaneous use of structurally distinct CTA classes, dithiobenzoate (DTB) and trithiocarbonate (TTC), enhances polymerization control and brush growth rates. The conditions enable the fabrication of poly(HPMAm) brushes exceeding 70 nm in thickness within only 4 h at 50 °C. Spectroscopic ellipsometry confirmed that the mixed-CTA approach significantly outperforms single-CTA systems, yielding higher polymerization efficiency and greater brush thickness. Additionally, size exclusion chromatography (SEC) confirmed that the solution-born polymers exhibited narrow dispersity (Ð = 1.05–1.15), ensuring well-defined polymer structures. The findings highlight the advantages of combining different CTAs in a single polymerization system, leading to a more efficient and scalable method for fabricating antifouling poly(HPMAm) coatings. This approach offers a significant potential for biomedical applications, including biosensors, blood-contacting devices, and implantable materials.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Advanced Materials Interfaces

ISSN

2196-7350

e-ISSN

2196-7350

Svazek periodika

12

Číslo periodika v rámci svazku

13

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

2500196

Kód UT WoS článku

001493277700001

EID výsledku v databázi Scopus

2-s2.0-105006618523