Synthesis of morphologically diverse dual thermo- and pH-responsive nano-objects via RAFT-mediated emulsion PISA

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00641357" target="_blank" >RIV/61389013:_____/25:00641357 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlelanding/2025/na/d5na00779h" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2025/na/d5na00779h</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/D5NA00779H" target="_blank" >10.1039/D5NA00779H</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis of morphologically diverse dual thermo- and pH-responsive nano-objects via RAFT-mediated emulsion PISA

Popis výsledku v původním jazyce

We report a versatile and efficient strategy for the synthesis of dual thermo- and pH-responsive polymeric nano-objects with rich morphological diversity, achieved via RAFT-mediated aqueous emulsion polymerization-induced self-assembly (PISA). Using a thermoresponsive poly(triethylene glycol methyl ether methacrylate) (PTEGMA) macro-chain transfer agent and a pH-sensitive diisopropylaminoethyl methacrylate (DPA) monomer, we generated PTEGMA-b-PDPA diblock copolymer nano-objects under conditions both below and above the LCST of PTEGMA. By systematically varying the length of the PDPA block, we accessed a wide array of morphologies—including micelles, worms, vesicles, and intricate “octopus”-like structures—simply by adjusting the polymerization temperature and hydrophobic block length. These nanostructures displayed clear dual responsiveness: thermally triggered aggregation around ∼40 °C and reversible disassembly in acidic environments. Our findings highlight the precise morphological control achievable through aqueous RAFT-PISA and underscore its potential for designing smart nanomaterials tailored for biomedical and stimuli-responsive applications.

Název v anglickém jazyce

Synthesis of morphologically diverse dual thermo- and pH-responsive nano-objects via RAFT-mediated emulsion PISA

Popis výsledku anglicky

We report a versatile and efficient strategy for the synthesis of dual thermo- and pH-responsive polymeric nano-objects with rich morphological diversity, achieved via RAFT-mediated aqueous emulsion polymerization-induced self-assembly (PISA). Using a thermoresponsive poly(triethylene glycol methyl ether methacrylate) (PTEGMA) macro-chain transfer agent and a pH-sensitive diisopropylaminoethyl methacrylate (DPA) monomer, we generated PTEGMA-b-PDPA diblock copolymer nano-objects under conditions both below and above the LCST of PTEGMA. By systematically varying the length of the PDPA block, we accessed a wide array of morphologies—including micelles, worms, vesicles, and intricate “octopus”-like structures—simply by adjusting the polymerization temperature and hydrophobic block length. These nanostructures displayed clear dual responsiveness: thermally triggered aggregation around ∼40 °C and reversible disassembly in acidic environments. Our findings highlight the precise morphological control achievable through aqueous RAFT-PISA and underscore its potential for designing smart nanomaterials tailored for biomedical and stimuli-responsive applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nanoscale Advances

ISSN

2516-0230

e-ISSN

2516-0230

Svazek periodika

7

Číslo periodika v rámci svazku

24

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

8023-8036

Kód UT WoS článku

001606690200001

EID výsledku v databázi Scopus

2-s2.0-105023490661