Enzymatic etching of PLA/hydroxyapatite scaffolds for improved cell adhesion: surface modification and homogeneity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00646595" target="_blank" >RIV/61389013:_____/25:00646595 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s42247-025-01087-8" target="_blank" >https://link.springer.com/article/10.1007/s42247-025-01087-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s42247-025-01087-8" target="_blank" >10.1007/s42247-025-01087-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Enzymatic etching of PLA/hydroxyapatite scaffolds for improved cell adhesion: surface modification and homogeneity

Popis výsledku v původním jazyce

Nanosized hydroxyapatite (HAP) particles were produced by precipitation, and poly(lactic acid) (PLA) composites containing 5 wt% of the nano HAP were prepared in an internal mixer to prepare scaffold materials. The nanoparticles aggregated without surface modification. Applying stearic acid coating on HAP particles decreased aggregation and improved homogeneity. The extent of coating must be optimized, the amount of stearic acid needed for monolayer coverage is around 4 wt% for the HAP prepared. A polymer layer always forms on the surface of PLA products during the melt processing of PLA/HAP composites, HAP particles are not available to help bone regeneration. The surface layer was removed successfully by enzymatic etching. The amount of removed PLA polymer depended quite strongly on the extent of surface coating. Etching disclosed the HAP particles, which led to increased surface roughness and decreased wettability, but this did not influence the adhesion of cells on the surface. Scaffolds could be prepared successfully by 3D printing from the composites containing the coated particles, which, in all probability, can be successfully used for bone regeneration.

Název v anglickém jazyce

Enzymatic etching of PLA/hydroxyapatite scaffolds for improved cell adhesion: surface modification and homogeneity

Popis výsledku anglicky

Nanosized hydroxyapatite (HAP) particles were produced by precipitation, and poly(lactic acid) (PLA) composites containing 5 wt% of the nano HAP were prepared in an internal mixer to prepare scaffold materials. The nanoparticles aggregated without surface modification. Applying stearic acid coating on HAP particles decreased aggregation and improved homogeneity. The extent of coating must be optimized, the amount of stearic acid needed for monolayer coverage is around 4 wt% for the HAP prepared. A polymer layer always forms on the surface of PLA products during the melt processing of PLA/HAP composites, HAP particles are not available to help bone regeneration. The surface layer was removed successfully by enzymatic etching. The amount of removed PLA polymer depended quite strongly on the extent of surface coating. Etching disclosed the HAP particles, which led to increased surface roughness and decreased wettability, but this did not influence the adhesion of cells on the surface. Scaffolds could be prepared successfully by 3D printing from the composites containing the coated particles, which, in all probability, can be successfully used for bone regeneration.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Emergent Materials

ISSN

2522-5731

e-ISSN

2522-574X

Svazek periodika

8

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

13

Strana od-do

6509-6521

Kód UT WoS článku

001471144400001

EID výsledku v databázi Scopus

2-s2.0-105003141241