Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F14%3A00429537" target="_blank" >RIV/61389030:_____/14:00429537 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2014/178931" target="_blank" >http://dx.doi.org/10.1155/2014/178931</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2014/178931" target="_blank" >10.1155/2014/178931</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity

Popis výsledku v původním jazyce

Cyclooxygenases and lipoxygenases are proinflammatory enzymes; the former affects platelet aggregation, vasoconstriction, vasodilatation and later the development of atherosclerosis. Red wines from Georgia and central and western Europe inhibited cyclooxygenase-1 (COX-1) activity in the range of 63-94%, cyclooxygenase-2 (COX-2) activity in the range of 20-44% (tested at a concentration of 5 mL/L), and 5-lipoxygenase (5-LOX) activity in the range of 72-84% (at a concentration of 18.87 mL/L). White winesinhibited 5-LOX in the range of 41-68% at a concentration of 18.87 mL/L and did not inhibit COX-1 and COX-2. Piceatannol (IC50 = 0.76 mu M) was identified as a strong inhibitor of 5-LOX followed by luteolin (IC50 = 2.25 mu M), quercetin (IC50 = 3.29 mu M), and myricetin (IC50 - 4.02 mu M). trans-Resveratrol was identified as an inhibitor of COX-1 (IC50 - 2.27 mu M) and COX-2 (IC50 - 3.40 mu M). Red wine as a complex mixture is a powerful inhibitor of COX-1, COX-2, and 5-LOX, the enzymes

Název v anglickém jazyce

Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity

Popis výsledku anglicky

Cyclooxygenases and lipoxygenases are proinflammatory enzymes; the former affects platelet aggregation, vasoconstriction, vasodilatation and later the development of atherosclerosis. Red wines from Georgia and central and western Europe inhibited cyclooxygenase-1 (COX-1) activity in the range of 63-94%, cyclooxygenase-2 (COX-2) activity in the range of 20-44% (tested at a concentration of 5 mL/L), and 5-lipoxygenase (5-LOX) activity in the range of 72-84% (at a concentration of 18.87 mL/L). White winesinhibited 5-LOX in the range of 41-68% at a concentration of 18.87 mL/L and did not inhibit COX-1 and COX-2. Piceatannol (IC50 = 0.76 mu M) was identified as a strong inhibitor of 5-LOX followed by luteolin (IC50 = 2.25 mu M), quercetin (IC50 = 3.29 mu M), and myricetin (IC50 - 4.02 mu M). trans-Resveratrol was identified as an inhibitor of COX-1 (IC50 - 2.27 mu M) and COX-2 (IC50 - 3.40 mu M). Red wine as a complex mixture is a powerful inhibitor of COX-1, COX-2, and 5-LOX, the enzymes

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GM - Potravinářství

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mediators of Inflammation

ISSN

0962-9351

e-ISSN

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Svazek periodika

2014

Číslo periodika v rámci svazku

UNSP 178931

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000337438400001

EID výsledku v databázi Scopus

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