Effect of Dietary Stilbenes on 5-Lipoxygenase and Cyclooxygenases Activities In Vitro
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F15%3A00446931" target="_blank" >RIV/61389030:_____/15:00446931 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60460709:41340/15:67484
Výsledek na webu
<a href="http://dx.doi.org/10.1080/10942912.2014.903416" target="_blank" >http://dx.doi.org/10.1080/10942912.2014.903416</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/10942912.2014.903416" target="_blank" >10.1080/10942912.2014.903416</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Effect of Dietary Stilbenes on 5-Lipoxygenase and Cyclooxygenases Activities In Vitro
Popis výsledku v původním jazyce
Stilbenes contained in various foods are associated with health beneficial effects. In this study six natural and one synthetic stilbene were tested for their potential to regulate the activity of lipoxygenase and cyclooxygenase in vitro. The most potentinhibitor of 5-lipoxygenase was pterostilbene (IC50 = 9.32 mu M), whereas the strongest inhibitor of cyclooxygenase-1 and cyclooxygenase-2 was pinostilbene (IC50s = 1.90 and 0.35 mu M, respectively). Pterostilbene (IC50s = 11.70 and 27.04 mu M for cyclooxygenase-1 and cyclooxygenase-2, respectively) and oxyresveratrol (IC50s = 18.49; 2.79 and 14.71 mu M for 5-lipoxygenase, cyclooxygenase-1, and cyclooxygenase-2, respectively) were capable to inhibit catalytic activity of all three tested enzymes. Isorhapontigenin (IC50s = 8.81 and 24.00 mu M for cyclooxygenase-1 and cyclooxygenase-2, respectively) and rhapontigenin (IC50s = 24.55 and 36.12 mu M for cyclooxygenase-1 and cyclooxygenase-2, respectively) were only moderate or weak inhibito
Název v anglickém jazyce
Effect of Dietary Stilbenes on 5-Lipoxygenase and Cyclooxygenases Activities In Vitro
Popis výsledku anglicky
Stilbenes contained in various foods are associated with health beneficial effects. In this study six natural and one synthetic stilbene were tested for their potential to regulate the activity of lipoxygenase and cyclooxygenase in vitro. The most potentinhibitor of 5-lipoxygenase was pterostilbene (IC50 = 9.32 mu M), whereas the strongest inhibitor of cyclooxygenase-1 and cyclooxygenase-2 was pinostilbene (IC50s = 1.90 and 0.35 mu M, respectively). Pterostilbene (IC50s = 11.70 and 27.04 mu M for cyclooxygenase-1 and cyclooxygenase-2, respectively) and oxyresveratrol (IC50s = 18.49; 2.79 and 14.71 mu M for 5-lipoxygenase, cyclooxygenase-1, and cyclooxygenase-2, respectively) were capable to inhibit catalytic activity of all three tested enzymes. Isorhapontigenin (IC50s = 8.81 and 24.00 mu M for cyclooxygenase-1 and cyclooxygenase-2, respectively) and rhapontigenin (IC50s = 24.55 and 36.12 mu M for cyclooxygenase-1 and cyclooxygenase-2, respectively) were only moderate or weak inhibito
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EI - Biotechnologie a bionika
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/LH12164" target="_blank" >LH12164: In vitro produkce biomasy Dendrobium candidum a studium její biologické aktivity</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
International Journal of Food Properties
ISSN
1094-2912
e-ISSN
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Svazek periodika
18
Číslo periodika v rámci svazku
7
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
7
Strana od-do
1471-1477
Kód UT WoS článku
000355244800009
EID výsledku v databázi Scopus
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