Triterpenoid Building Blocks for Functional Nanoscale Assemblies: A Review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F22%3A00564512" target="_blank" >RIV/61389030:_____/22:00564512 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/22:43924766

Výsledek na webu

<a href="https://doi.org/10.1021/acsanm.2c03304" target="_blank" >https://doi.org/10.1021/acsanm.2c03304</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsanm.2c03304" target="_blank" >10.1021/acsanm.2c03304</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Triterpenoid Building Blocks for Functional Nanoscale Assemblies: A Review

Popis výsledku v původním jazyce

Naturally abundant, renewable, and sustainable plant triterpenoids have gained considerable attention in biological application, including antitumor activities. However, due to their lipophilic nature, natural triterpenoids display limited solubility in aqueous media. Notably, the rigid backbone and the presence of functional groups also offer the possibilities toward a strategic design of a class of conformationally rigid amphiphiles. Such derivatives may improve their bioavailability, and they display unique self-assembly properties relevant for soft functional materials. In recent years, a formation of nano-assemblies has been studied with plant triterpenoids and their semisynthetic derivatives to investigate ways of their applications in materials science. For example, naturally amphiphilic glycyrrhizic acid has been shown to form hydrogels. Similarly, other natural triterpenoid-based phosphates or heterocyclic-based quaternary conjugates have also been studied for supramolecular gelation. Triterpenoid-based supramolecular gels are important types of soft materials, displaying rapid self-healing, thixotropic behaviors, aging-induced transition, and self-assembly-induced anticancer and antimicrobial properties. In this review, we will provide a summary of (i) unique structural and functional properties of natural triterpenoids, (ii) self-assembly and gelation properties of natural triterpenoids, (iii) gelation properties of rationally designed triterpenoid derivatives, (iv) structural transition in aqueous media, and (v) their biological effects.

Název v anglickém jazyce

Triterpenoid Building Blocks for Functional Nanoscale Assemblies: A Review

Popis výsledku anglicky

Naturally abundant, renewable, and sustainable plant triterpenoids have gained considerable attention in biological application, including antitumor activities. However, due to their lipophilic nature, natural triterpenoids display limited solubility in aqueous media. Notably, the rigid backbone and the presence of functional groups also offer the possibilities toward a strategic design of a class of conformationally rigid amphiphiles. Such derivatives may improve their bioavailability, and they display unique self-assembly properties relevant for soft functional materials. In recent years, a formation of nano-assemblies has been studied with plant triterpenoids and their semisynthetic derivatives to investigate ways of their applications in materials science. For example, naturally amphiphilic glycyrrhizic acid has been shown to form hydrogels. Similarly, other natural triterpenoid-based phosphates or heterocyclic-based quaternary conjugates have also been studied for supramolecular gelation. Triterpenoid-based supramolecular gels are important types of soft materials, displaying rapid self-healing, thixotropic behaviors, aging-induced transition, and self-assembly-induced anticancer and antimicrobial properties. In this review, we will provide a summary of (i) unique structural and functional properties of natural triterpenoids, (ii) self-assembly and gelation properties of natural triterpenoids, (iii) gelation properties of rationally designed triterpenoid derivatives, (iv) structural transition in aqueous media, and (v) their biological effects.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

<a href="/cs/project/FV10599" target="_blank" >FV10599: Gely na bázi triterpenoidních kyselin</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Applied Nano Materials

ISSN

2574-0970

e-ISSN

—

Svazek periodika

5

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

16264-16277

Kód UT WoS článku

000882971600001

EID výsledku v databázi Scopus

2-s2.0-85141640278