Chronobiological Aspects of Ketamine/Xylazine Anaesthesia Impact on the Cardiovascular System, the Acid-base Balance, Ions and Autonomic Nervous System in Wistar Rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F13%3AA130173K" target="_blank" >RIV/61988987:17110/13:A130173K - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Chronobiological Aspects of Ketamine/Xylazine Anaesthesia Impact on the Cardiovascular System, the Acid-base Balance, Ions and Autonomic Nervous System in Wistar Rats

Popis výsledku v původním jazyce

The creation of experimental, in vivo, chronobiological animal models may help to reveal some of the relationships between circadian rhythmsand biological function, which is sometimes very difficult to study in humans.However, in vivo experiments requirethe use of appropriate anaesthesia, which should be selected according to their particular effect on the organism. Using an animal model, the aim of the present study was to evaluate the chronobiological effects of ketamine/xylazine anaesthesia in spontaneously breathing rats. Study was performed in female Wistar rats (10mg/kg/15mg/kg, i.m)after adaptation to a LD cycle of 12 hours light:12 hours dark. Heart rate, rectal temperature, electrocardiographic parameters, autonomic nervous system activity, acid-base balance and Na+, K+, Ca2+ and Cl- plasma concentrations in arterial blood were evaluated in their dependence on the active (dark) and non-active (light) parts of the LD cycle.

Název v anglickém jazyce

Chronobiological Aspects of Ketamine/Xylazine Anaesthesia Impact on the Cardiovascular System, the Acid-base Balance, Ions and Autonomic Nervous System in Wistar Rats

Popis výsledku anglicky

The creation of experimental, in vivo, chronobiological animal models may help to reveal some of the relationships between circadian rhythmsand biological function, which is sometimes very difficult to study in humans.However, in vivo experiments requirethe use of appropriate anaesthesia, which should be selected according to their particular effect on the organism. Using an animal model, the aim of the present study was to evaluate the chronobiological effects of ketamine/xylazine anaesthesia in spontaneously breathing rats. Study was performed in female Wistar rats (10mg/kg/15mg/kg, i.m)after adaptation to a LD cycle of 12 hours light:12 hours dark. Heart rate, rectal temperature, electrocardiographic parameters, autonomic nervous system activity, acid-base balance and Na+, K+, Ca2+ and Cl- plasma concentrations in arterial blood were evaluated in their dependence on the active (dark) and non-active (light) parts of the LD cycle.

Druh

C - Kapitola v odborné knize

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Horizons in Neuroscience Research Volume 10

ISBN

978-1-62417-003-4

Počet stran výsledku

15

Strana od-do

205-219

Počet stran knihy

238

Název nakladatele

Nova Science Publishers, Inc.

Místo vydání

New York, USA

Kód UT WoS kapitoly

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