What Does Antidepressant Drug level Monitoring Reveal About Outpatient Treatment and Patient Adherence?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F19%3AA2001XY4" target="_blank" >RIV/61988987:17110/19:A2001XY4 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00843989:_____/19:E0107718

Výsledek na webu

<a href="https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0044-101838" target="_blank" >https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0044-101838</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1055/s-0044-101838" target="_blank" >10.1055/s-0044-101838</a>

Jazyk výsledku

angličtina

Název v původním jazyce

What Does Antidepressant Drug level Monitoring Reveal About Outpatient Treatment and Patient Adherence?

Popis výsledku v původním jazyce

Introduction The evaluation of plasma levels of antidepressants may improve the treatment outcome. The aim was to verify adherence and adequacy of administered doses of antidepressants among patients hospitalized for inadequate outpatient therapeutic response. Methods Selective serotonin reuptake inhibitors or venlafaxine plasma levels were assessed on the first day of hospitalization and after 3 days of controlled administration. The patients were considered adherent if the plasma level on admission was within the interval of the minimum and maximum plasma level on the fourth day, expanded by 30%. The adequacy of antidepressant doses used during the outpatient treatment was assessed by comparing the plasma level on the fourth day with the therapeutic reference range. Results Out of 83 patients, 52 (62.7%) were adherent. The plasma levels of antidepressants on the fourth day were found to be within the therapeutic reference range in 35 (43.2%) patients. The same number manifested levels below the therapeutic reference range. In 11 (13.6%) patients, the levels were higher than recommended. No significant difference in rate of adherence was found among individual antidepressants. Conclusion The results show that antidepressant nonresponders are frequently under-dosed or nonadherent.

Název v anglickém jazyce

What Does Antidepressant Drug level Monitoring Reveal About Outpatient Treatment and Patient Adherence?

Popis výsledku anglicky

Introduction The evaluation of plasma levels of antidepressants may improve the treatment outcome. The aim was to verify adherence and adequacy of administered doses of antidepressants among patients hospitalized for inadequate outpatient therapeutic response. Methods Selective serotonin reuptake inhibitors or venlafaxine plasma levels were assessed on the first day of hospitalization and after 3 days of controlled administration. The patients were considered adherent if the plasma level on admission was within the interval of the minimum and maximum plasma level on the fourth day, expanded by 30%. The adequacy of antidepressant doses used during the outpatient treatment was assessed by comparing the plasma level on the fourth day with the therapeutic reference range. Results Out of 83 patients, 52 (62.7%) were adherent. The plasma levels of antidepressants on the fourth day were found to be within the therapeutic reference range in 35 (43.2%) patients. The same number manifested levels below the therapeutic reference range. In 11 (13.6%) patients, the levels were higher than recommended. No significant difference in rate of adherence was found among individual antidepressants. Conclusion The results show that antidepressant nonresponders are frequently under-dosed or nonadherent.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pharmacopsychiatry

ISSN

0176-3679

e-ISSN

1439-0795

Svazek periodika

52

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

78-83

Kód UT WoS článku

000460173800004

EID výsledku v databázi Scopus

2-s2.0-85042231947