Global analysis of inverted repeat sequences in human gene promoters reveals their non-random distribution and association with speci fic biological pathways
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F20%3AA21027WP" target="_blank" >RIV/61988987:17310/20:A21027WP - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68081707:_____/20:00539353 RIV/62156489:43110/20:43917709
Výsledek na webu
<a href="https://www.sciencedirect.com/science/article/pii/S088875431930850X" target="_blank" >https://www.sciencedirect.com/science/article/pii/S088875431930850X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ygeno.2020.03.014" target="_blank" >10.1016/j.ygeno.2020.03.014</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Global analysis of inverted repeat sequences in human gene promoters reveals their non-random distribution and association with speci fic biological pathways
Popis výsledku v původním jazyce
Inverted repeats (IR) play important roles in specific DNA-dependent processes in simple prokaryotes to complex eukaryotes. They are recognized by a variety of proteins including restriction enzymes, helicases and transcription factors. We evaluate the presence and localization of IRs in all validated human promoter sequences within 1000 bp upstream and downstream of the transcription start site (TSS). The occurrence of 7 bp and longer IRs is located non-randomly in promoter regions, with enrichment within 200 bp upstream of the TSS. The highest frequency of IRs is just before TSS for repeats of 8 bp or longer. A comparison of promoters divided according to the occurrence of five individual promoter motifs shows unique location patterns of IRs. Principal component analyses and hierarchical clustering of IRs abundance demonstrated that they are depleted and/or not enriched in the promoters of stably expressed genes, but show significant enrichments for specific dynamically regulated biological pathways.
Název v anglickém jazyce
Global analysis of inverted repeat sequences in human gene promoters reveals their non-random distribution and association with speci fic biological pathways
Popis výsledku anglicky
Inverted repeats (IR) play important roles in specific DNA-dependent processes in simple prokaryotes to complex eukaryotes. They are recognized by a variety of proteins including restriction enzymes, helicases and transcription factors. We evaluate the presence and localization of IRs in all validated human promoter sequences within 1000 bp upstream and downstream of the transcription start site (TSS). The occurrence of 7 bp and longer IRs is located non-randomly in promoter regions, with enrichment within 200 bp upstream of the TSS. The highest frequency of IRs is just before TSS for repeats of 8 bp or longer. A comparison of promoters divided according to the occurrence of five individual promoter motifs shows unique location patterns of IRs. Principal component analyses and hierarchical clustering of IRs abundance demonstrated that they are depleted and/or not enriched in the promoters of stably expressed genes, but show significant enrichments for specific dynamically regulated biological pathways.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10603 - Genetics and heredity (medical genetics to be 3)
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Genomics
ISSN
0888-7543
e-ISSN
—
Svazek periodika
112
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
6
Strana od-do
2772-2777
Kód UT WoS článku
000534479700011
EID výsledku v databázi Scopus
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