Chemoprotektivní vliv rostlinných fenolů vůči toxicitě indukované anthracyklinem u potkaních kardiomyocytů. Část II. Kávová, chlorogenová a rozmarýnová kyselina

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F04%3A00000786" target="_blank" >RIV/61989592:15110/04:00000786 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/04:00001953

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part II. Caffeic, chlorogenic and rosmarinic acids

Popis výsledku v původním jazyce

The chemoprotective effects of caffeic (CA), chlorogenic (CHA) and rosmarinic (RA) acids were tested against the toxicity of doxorubicin (DOX) in neonatal rat cardiomyocytes and the iron-dependent DOX induced lipid peroxidation of heart membranes, mitochondria and microsomes. The protectivity of these acids was compared with dexrazoxan, used as an adjuvant during DOX chemotherapy. The cytoprotective effects were assessed by enzyme (LDH and ASAT) and troponin I leakage, secondly by intracellular ATP content. All hydroxycinnamic acids proved non-cytotoxic, and they stabilized both membranes and the energetic status of cardiomyocytes. After preincubation of cardiomyocytes with the test compounds (100, 200 #m; 1 h) the cardiomyocytes were treated with thetoxic agent, DOX (100 #m; 8 h). The test compounds protected cardiomyocytes against DOX induced oxidative stress (RA > CHA CA) on all monitored parameters. Substantial preservation of monolayer integrity of the cardiomyocytes by test comp

Název v anglickém jazyce

Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part II. Caffeic, chlorogenic and rosmarinic acids

Popis výsledku anglicky

The chemoprotective effects of caffeic (CA), chlorogenic (CHA) and rosmarinic (RA) acids were tested against the toxicity of doxorubicin (DOX) in neonatal rat cardiomyocytes and the iron-dependent DOX induced lipid peroxidation of heart membranes, mitochondria and microsomes. The protectivity of these acids was compared with dexrazoxan, used as an adjuvant during DOX chemotherapy. The cytoprotective effects were assessed by enzyme (LDH and ASAT) and troponin I leakage, secondly by intracellular ATP content. All hydroxycinnamic acids proved non-cytotoxic, and they stabilized both membranes and the energetic status of cardiomyocytes. After preincubation of cardiomyocytes with the test compounds (100, 200 #m; 1 h) the cardiomyocytes were treated with thetoxic agent, DOX (100 #m; 8 h). The test compounds protected cardiomyocytes against DOX induced oxidative stress (RA > CHA CA) on all monitored parameters. Substantial preservation of monolayer integrity of the cardiomyocytes by test comp

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Phytotherapy Research

ISSN

0951-418X

e-ISSN

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Svazek periodika

18

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

408-413

Kód UT WoS článku

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EID výsledku v databázi Scopus

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