Ochranný efekt rostlinných fenolických látek proti toxicitě vyvolané anthracyklinem na krysích kardiomyocytech. Část III. Apigenin, baicalelin, kaempherol, luteolin a quercetin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F04%3A00002241" target="_blank" >RIV/61989592:15310/04:00002241 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/04:00000835

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin

Popis výsledku v původním jazyce

Flavonoids are found universally in plants and act as free radical scavenging and chelating agents with anti-inflammatory, antiischemic, vasodilating and chemoprotective properties. In this study, the antilipoperoxidative and cytoprotective effects of apigenin, baicalein, kaempferol, luteolin and quercetin against doxorubic-ininduced oxidative stress were investigated in isolated rat heart cardiac myocytes, mitochondria and microsomes. After preincubation of cardiomyocytes with the test compounds for 1It the cardiomyocytes were treated with the toxic agent, doxorubicin (100 muM for 8 h). Cardiomyocyte protection was assessed by extracellular LDH and cellular ADP and ATP production. Cytoprotection was concentration dependent for baicalein > luteolin congruent to apigenin > quercetin > kaempferol. All test compounds had significantly better protective effects than dexrazoxan, an agent currently used for adjuvant therapy during anthracycline antibiotic therapy. In microsomes/ mitochondri

Název v anglickém jazyce

Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin

Popis výsledku anglicky

Flavonoids are found universally in plants and act as free radical scavenging and chelating agents with anti-inflammatory, antiischemic, vasodilating and chemoprotective properties. In this study, the antilipoperoxidative and cytoprotective effects of apigenin, baicalein, kaempferol, luteolin and quercetin against doxorubic-ininduced oxidative stress were investigated in isolated rat heart cardiac myocytes, mitochondria and microsomes. After preincubation of cardiomyocytes with the test compounds for 1It the cardiomyocytes were treated with the toxic agent, doxorubicin (100 muM for 8 h). Cardiomyocyte protection was assessed by extracellular LDH and cellular ADP and ATP production. Cytoprotection was concentration dependent for baicalein > luteolin congruent to apigenin > quercetin > kaempferol. All test compounds had significantly better protective effects than dexrazoxan, an agent currently used for adjuvant therapy during anthracycline antibiotic therapy. In microsomes/ mitochondri

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Phytotherapy Research

ISSN

0951-418X

e-ISSN

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Svazek periodika

18

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

516-521

Kód UT WoS článku

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EID výsledku v databázi Scopus

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