De novo syntéza purinů -mechanismy a klinické implikace

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F05%3A00006109" target="_blank" >RIV/61989592:15110/05:00006109 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Purine de novo synthesis - mechanisms and clinical implications

Popis výsledku v původním jazyce

Purine de novo synthesis represents a basis for nucleotide metabolism as well as all other interconnected pathways. Synthesis of the purine ring de novo is required especially when DNA is replicated so that, although present in most tissues, the activityof the metabolic pathway is highly variable. Since the key experiments to discover functioning of the pathway were conducted in the fifties, it attracts substantial attention of researchers because inhibitors of the pathway are effective drugs against cancer, inflammatory disorders and various infections. There is substantial body of information on genes, proteins involved and regulation, however some questions concerning substrate channeling and interaction of the proteins remain open.

Název v anglickém jazyce

Purine de novo synthesis - mechanisms and clinical implications

Popis výsledku anglicky

Purine de novo synthesis represents a basis for nucleotide metabolism as well as all other interconnected pathways. Synthesis of the purine ring de novo is required especially when DNA is replicated so that, although present in most tissues, the activityof the metabolic pathway is highly variable. Since the key experiments to discover functioning of the pathway were conducted in the fifties, it attracts substantial attention of researchers because inhibitors of the pathway are effective drugs against cancer, inflammatory disorders and various infections. There is substantial body of information on genes, proteins involved and regulation, however some questions concerning substrate channeling and interaction of the proteins remain open.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/NR7796" target="_blank" >NR7796: DEFEKTY PURINOVÉ DE NOVO SYNTÉZY - METABOLICKÁ STUDIE</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Klinická biochemie a metabolismus

ISSN

1210-7921

e-ISSN

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Svazek periodika

13

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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