GPR30, nový estrogenový receptor v lidském endometriu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00007358" target="_blank" >RIV/61989592:15110/08:00007358 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

GPR30, a novel estrogen receptor in the human endometrium

Popis výsledku v původním jazyce

Purpose Estrogen effects mediated through the nuclear receptors (ER and ER) are predominantly implemented via genomic mechanism. ERs interact as transcript factors with estrogen responsive elements in target genes and evoke cellular response within hours. However, rapid cellular responses with a time lag of minutes or seconds do not involve the gen transcription and act presumably at the cell membrane. They result in activation of second messengers and kinase cascades signaling pathways, transactivationof EGFR, ect. Lately a high affinity receptor for estrogenic compounds has been identified as an orphan membrane G-protein coupled receptor 30 (GPR30). GPR30 acts independent of the nuclear receptors and suggests new approaches to contraceptives and hormonal targeted cancer therapy. The purpose of this study was to characterize expression and tissue distribution of GPR30 mRNA and its protein in endometrium during the menstrual cycle and during a pregnancy. Methods and Materials Endometr

Název v anglickém jazyce

GPR30, a novel estrogen receptor in the human endometrium

Popis výsledku anglicky

Purpose Estrogen effects mediated through the nuclear receptors (ER and ER) are predominantly implemented via genomic mechanism. ERs interact as transcript factors with estrogen responsive elements in target genes and evoke cellular response within hours. However, rapid cellular responses with a time lag of minutes or seconds do not involve the gen transcription and act presumably at the cell membrane. They result in activation of second messengers and kinase cascades signaling pathways, transactivationof EGFR, ect. Lately a high affinity receptor for estrogenic compounds has been identified as an orphan membrane G-protein coupled receptor 30 (GPR30). GPR30 acts independent of the nuclear receptors and suggests new approaches to contraceptives and hormonal targeted cancer therapy. The purpose of this study was to characterize expression and tissue distribution of GPR30 mRNA and its protein in endometrium during the menstrual cycle and during a pregnancy. Methods and Materials Endometr

Druh

A - Audiovizuální tvorba

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

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Místo vydání

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Název nakladatele resp. objednatele

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Verze

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Identifikační číslo nosiče

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