PRUNELLA VULGARIS EXTRACT AND ROSMARINIC ACID SUPPRESS LIPOPOLYSACCHARIDE-INDUCED ALTERATION IN HUMAN GINGIVAL FIBROBLASTS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F09%3A00009496" target="_blank" >RIV/61989592:15110/09:00009496 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

PRUNELLA VULGARIS EXTRACT AND ROSMARINIC ACID SUPPRESS LIPOPOLYSACCHARIDE-INDUCED ALTERATION IN HUMAN GINGIVAL FIBROBLASTS

Popis výsledku v původním jazyce

Periodontitis is a chronic disease associated with inflammation of the tooth-supporting tissues. The inflammation is initiated by a group of gram-negative anaerobic bacteria. These express a number of irritating factors including a lipopolysaccharide (LPS), which plays a key role in periodontal disease development. Plant extracts with anti-inflammatory and anti-microbial properties have been shown to inhibit bacterial plaque formation and thus prevent chronic gingivitis. In this study we tested effectsof Prunella vulgaris L. extract (PVE; 5, 10, 25 ?g/ml) and its component rosmarinic acid (RA; 1 ?g/ml) on LPS-induced oxidative damage and inflammation in human gingival fibroblasts. PVE and RA reduced reactive oxygen species (ROS) production, intracellular glutathione (GSH) depletion as well as lipid peroxidation in LPS-treated cells. Treatment with PVE and RA also inhibited LPS-induced up-regulation of interleukin 1? (IL-1?), interleukin 6 (IL-6), tumor necrosis factor-? (TNF) and supp

Název v anglickém jazyce

PRUNELLA VULGARIS EXTRACT AND ROSMARINIC ACID SUPPRESS LIPOPOLYSACCHARIDE-INDUCED ALTERATION IN HUMAN GINGIVAL FIBROBLASTS

Popis výsledku anglicky

Periodontitis is a chronic disease associated with inflammation of the tooth-supporting tissues. The inflammation is initiated by a group of gram-negative anaerobic bacteria. These express a number of irritating factors including a lipopolysaccharide (LPS), which plays a key role in periodontal disease development. Plant extracts with anti-inflammatory and anti-microbial properties have been shown to inhibit bacterial plaque formation and thus prevent chronic gingivitis. In this study we tested effectsof Prunella vulgaris L. extract (PVE; 5, 10, 25 ?g/ml) and its component rosmarinic acid (RA; 1 ?g/ml) on LPS-induced oxidative damage and inflammation in human gingival fibroblasts. PVE and RA reduced reactive oxygen species (ROS) production, intracellular glutathione (GSH) depletion as well as lipid peroxidation in LPS-treated cells. Treatment with PVE and RA also inhibited LPS-induced up-regulation of interleukin 1? (IL-1?), interleukin 6 (IL-6), tumor necrosis factor-? (TNF) and supp

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Toxicology in Vitro

ISSN

0887-2333

e-ISSN

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Svazek periodika

23

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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