Methylation of AR locus does not always reflect X chromosome inactivation state
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33141042" target="_blank" >RIV/61989592:15110/12:33141042 - isvavai.cz</a>
Výsledek na webu
<a href="http://bloodjournal.hematologylibrary.org/content/119/13/e100.full.pdf+html" target="_blank" >http://bloodjournal.hematologylibrary.org/content/119/13/e100.full.pdf+html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1182/blood-2011-11-390351" target="_blank" >10.1182/blood-2011-11-390351</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Methylation of AR locus does not always reflect X chromosome inactivation state
Popis výsledku v původním jazyce
Determination of clonality on the basis of assays of inactivation of genes encoded on the X chromosome has provided important insights into the origins of neoplastic diseases, helped to decipher the hierarchy of hematopoiesis, and provided a mechanism for differentiating between inherited and acquired disorders, for distinguishing between clonal and reactive acquired hematologic abnormalities and for showing cell selection in female carriers of X-linked inherited processes. The methylation status of CpGsites close to the trinucleotide repeats in exon 1 of the human androgen receptor (AR) X chromosome gene assay (HUMARA) has been used to determine clonality. This HUMARA at times indicated clonal hematopoiesis in healthy elderly women, thus precluding its applicability. We used a clonality assay based on quantitative expression of polymorphic X chromosome genes (qTCA) and found no evidence of clonal hematopoiesis in healthy nonanemic elderly persons. These data provide the molecular bas
Název v anglickém jazyce
Methylation of AR locus does not always reflect X chromosome inactivation state
Popis výsledku anglicky
Determination of clonality on the basis of assays of inactivation of genes encoded on the X chromosome has provided important insights into the origins of neoplastic diseases, helped to decipher the hierarchy of hematopoiesis, and provided a mechanism for differentiating between inherited and acquired disorders, for distinguishing between clonal and reactive acquired hematologic abnormalities and for showing cell selection in female carriers of X-linked inherited processes. The methylation status of CpGsites close to the trinucleotide repeats in exon 1 of the human androgen receptor (AR) X chromosome gene assay (HUMARA) has been used to determine clonality. This HUMARA at times indicated clonal hematopoiesis in healthy elderly women, thus precluding its applicability. We used a clonality assay based on quantitative expression of polymorphic X chromosome genes (qTCA) and found no evidence of clonal hematopoiesis in healthy nonanemic elderly persons. These data provide the molecular bas
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Blood
ISSN
0006-4971
e-ISSN
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Svazek periodika
119
Číslo periodika v rámci svazku
13
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
10
Strana od-do
"e100"-"e109"
Kód UT WoS článku
000302141200001
EID výsledku v databázi Scopus
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