Acute Lymphoblastic Leukemia in a Child With Leri-Weill Syndrome and Complete SHOX Gene Deletion: A Case Report
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73590291" target="_blank" >RIV/61989592:15110/18:73590291 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.5507/bp.2018.002" target="_blank" >http://dx.doi.org/10.5507/bp.2018.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2018.002" target="_blank" >10.5507/bp.2018.002</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Acute Lymphoblastic Leukemia in a Child With Leri-Weill Syndrome and Complete SHOX Gene Deletion: A Case Report
Popis výsledku v původním jazyce
Background. Leri-Weill syndrome (LWS) ranks among conditions with short stature homeobox gene (SHOX) haploinsufficiency. Data on possible association of SHOX aberrations with malignant diseases are scarce. Methods and Results. We report a unique case of an 8-year-old girl who was successfully treated for acute lymphoblastic leukemia (pre-B ALL, intermediate risk) and was subsequently diagnosed with LWS due to characteristic clinical appearance (short disproportionate stature, Madelung deformity of the wrist) and molecular genetic examination (complete deletion of SHOX). An identical SHOX deletion was identified also in the patient's mother. Leukemic cells of the patient were retrospectively examined by array comparative genomic hybridization (aCGH), which revealed five regions of deletions at chromosome X, including the SHOX gene locus. Conclusion. Growth retardation in children with hemato-oncologic malignancies cannot always be attributed to cytotoxic treatment and should be carefully evaluated, especially with regards to growth hormone therapy.
Název v anglickém jazyce
Acute Lymphoblastic Leukemia in a Child With Leri-Weill Syndrome and Complete SHOX Gene Deletion: A Case Report
Popis výsledku anglicky
Background. Leri-Weill syndrome (LWS) ranks among conditions with short stature homeobox gene (SHOX) haploinsufficiency. Data on possible association of SHOX aberrations with malignant diseases are scarce. Methods and Results. We report a unique case of an 8-year-old girl who was successfully treated for acute lymphoblastic leukemia (pre-B ALL, intermediate risk) and was subsequently diagnosed with LWS due to characteristic clinical appearance (short disproportionate stature, Madelung deformity of the wrist) and molecular genetic examination (complete deletion of SHOX). An identical SHOX deletion was identified also in the patient's mother. Leukemic cells of the patient were retrospectively examined by array comparative genomic hybridization (aCGH), which revealed five regions of deletions at chromosome X, including the SHOX gene locus. Conclusion. Growth retardation in children with hemato-oncologic malignancies cannot always be attributed to cytotoxic treatment and should be carefully evaluated, especially with regards to growth hormone therapy.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30209 - Paediatrics
Návaznosti výsledku
Projekt
<a href="/cs/project/LO1304" target="_blank" >LO1304: Podpora udržitelnosti Ústavu molekulární a translační medicíny</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
BIOMEDICAL PAPERS-OLOMOUC
ISSN
1213-8118
e-ISSN
—
Svazek periodika
162
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
6
Strana od-do
65-70
Kód UT WoS článku
000428951000012
EID výsledku v databázi Scopus
2-s2.0-85044744312