Amino-BODIPY as the Ratiometric Fluorescent Sensor for Monitoring Drug Release or “Power Supply” Selector for Molecular Electronics

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73597559" target="_blank" >RIV/61989592:15110/19:73597559 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/19:73597559

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlepdf/2019/ra/c9ra03472b" target="_blank" >https://pubs.rsc.org/en/content/articlepdf/2019/ra/c9ra03472b</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/C9RA03472B" target="_blank" >10.1039/C9RA03472B</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Amino-BODIPY as the Ratiometric Fluorescent Sensor for Monitoring Drug Release or “Power Supply” Selector for Molecular Electronics

Popis výsledku v původním jazyce

The glutathione cleavable conjugates of amino-BODIPY dye with model drugs have been tested for monitoring the drug release via ratiometric fluorescence based on two excitation and one emission wavelengths. As the self-immolative linker was used for the construction of conjugates, free amino-BODIPY was released with the drug. Different excitation profiles of the dye before and after conjugate cleavage and similar emission wavelengths that enabled monitoring the release of the drug via the OFF-ON effect were successfully tested inside the cancer cells. UV/VIS spectrometry could be used in the quantification of the conjugate/drug in an analyte irrespective of the cleavage grade. As the system functionality was based only on the altered acylamino-BODIPY present in the conjugate to amino-BODIPY released during the cleavage, the method could be applied as a ratiometric fluorescence theranostic system to other non-fluorescent drugs. Therefore, the present conjugates demonstrated their potential application in molecular electronics as a “power supply” selector enabling the application of two power sources for one “bulb” to maintain its light intensity.

Název v anglickém jazyce

Amino-BODIPY as the Ratiometric Fluorescent Sensor for Monitoring Drug Release or “Power Supply” Selector for Molecular Electronics

Popis výsledku anglicky

The glutathione cleavable conjugates of amino-BODIPY dye with model drugs have been tested for monitoring the drug release via ratiometric fluorescence based on two excitation and one emission wavelengths. As the self-immolative linker was used for the construction of conjugates, free amino-BODIPY was released with the drug. Different excitation profiles of the dye before and after conjugate cleavage and similar emission wavelengths that enabled monitoring the release of the drug via the OFF-ON effect were successfully tested inside the cancer cells. UV/VIS spectrometry could be used in the quantification of the conjugate/drug in an analyte irrespective of the cleavage grade. As the system functionality was based only on the altered acylamino-BODIPY present in the conjugate to amino-BODIPY released during the cleavage, the method could be applied as a ratiometric fluorescence theranostic system to other non-fluorescent drugs. Therefore, the present conjugates demonstrated their potential application in molecular electronics as a “power supply” selector enabling the application of two power sources for one “bulb” to maintain its light intensity.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

RSC Advances

ISSN

2046-2069

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

43

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

"25075–25083"

Kód UT WoS článku

000481573800046

EID výsledku v databázi Scopus

2-s2.0-85070833210