FliC-Specific CD4+T Cell Responses Are Restricted by Bacterial Regulation of Antigen Expression

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F05%3A00010747" target="_blank" >RIV/61989592:15310/05:00010747 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

FliC-Specific CD4+T Cell Responses Are Restricted by Bacterial Regulation of Antigen Expression

Popis výsledku v původním jazyce

Salmonella typhimurium, a facultatively intracellular pathogen, regulates expression of virulence factors in response to distinct environments encountered during the course of infection. We tested the hypothesis that the transition from extra- to intracellular environments during Salmonella infection triggers changes in Ag expression that impose both temporal and spatial limitations on the host T cell response. CD4+ T cells recovered from Salmonella immune mice were propagated in vitro using Ag derivedfrom bacteria grown in conditions designed to emulate extra- or intracellular environments in vivo. Extracellular phase bakteria supported a dominant T cell response to the flagellar subunit protein FliC, whereas intracellular phase bacteria were unableto support expansion of FliC-specific T cells from populations known to contain T cells with reactivity to this Ag. This result was attributed to bacterial regulation of FliC expression: transcription and protein levels were repressed in

Název v anglickém jazyce

FliC-Specific CD4+T Cell Responses Are Restricted by Bacterial Regulation of Antigen Expression

Popis výsledku anglicky

Salmonella typhimurium, a facultatively intracellular pathogen, regulates expression of virulence factors in response to distinct environments encountered during the course of infection. We tested the hypothesis that the transition from extra- to intracellular environments during Salmonella infection triggers changes in Ag expression that impose both temporal and spatial limitations on the host T cell response. CD4+ T cells recovered from Salmonella immune mice were propagated in vitro using Ag derivedfrom bacteria grown in conditions designed to emulate extra- or intracellular environments in vivo. Extracellular phase bakteria supported a dominant T cell response to the flagellar subunit protein FliC, whereas intracellular phase bacteria were unableto support expansion of FliC-specific T cells from populations known to contain T cells with reactivity to this Ag. This result was attributed to bacterial regulation of FliC expression: transcription and protein levels were repressed in

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EG - Zoologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Immunology

ISSN

0022-1767

e-ISSN

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Svazek periodika

73

Číslo periodika v rámci svazku

174

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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