Interakce rostlinných aminoxidas s diaminoethery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F07%3A00004642" target="_blank" >RIV/61989592:15310/07:00004642 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389030:_____/07:00305982

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Interaction of plant amine oxidases with diaminoethers

Popis výsledku v původním jazyce

Polyamines are ubiquitous compounds, which are involved in crucial physiological events including cell growth and differentiation. The catabolic oxidative degradation of polyamines is catalyzed by quinoprotein copper-containing amine oxidases (CAOs) andflavoprotein polyamine oxidases (PAOs). Various synthetic polyamine analogs and polyamine derivatives have been reported, which represent important tools (substrates or inhibitors) in the study of catalytic properties of the enzymes. In this work, two related compounds were studied in the reactions with plant amine oxidases: 1,8-diamino-3,6-dioxaoctane (DADO) and 1,10-bis(2-pyridinylmethyl)-4,7-dioxa-1,10-diazadecane (BPDD). Based on activity and stoichiometry assays together with spectrophotometric measurements, DADO can be considered a good substrate for grass pea, lentil and E. characias CAOs with Km values in the range 10-4 ? 10-3 M. Its oxidative degradation produces the corresponding aminoaldehyde 8-amino-3,6-dioxaoctanal, which d

Název v anglickém jazyce

Interaction of plant amine oxidases with diaminoethers

Popis výsledku anglicky

Polyamines are ubiquitous compounds, which are involved in crucial physiological events including cell growth and differentiation. The catabolic oxidative degradation of polyamines is catalyzed by quinoprotein copper-containing amine oxidases (CAOs) andflavoprotein polyamine oxidases (PAOs). Various synthetic polyamine analogs and polyamine derivatives have been reported, which represent important tools (substrates or inhibitors) in the study of catalytic properties of the enzymes. In this work, two related compounds were studied in the reactions with plant amine oxidases: 1,8-diamino-3,6-dioxaoctane (DADO) and 1,10-bis(2-pyridinylmethyl)-4,7-dioxa-1,10-diazadecane (BPDD). Based on activity and stoichiometry assays together with spectrophotometric measurements, DADO can be considered a good substrate for grass pea, lentil and E. characias CAOs with Km values in the range 10-4 ? 10-3 M. Its oxidative degradation produces the corresponding aminoaldehyde 8-amino-3,6-dioxaoctanal, which d

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Arkivoc

ISSN

1424-6376

e-ISSN

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Svazek periodika

8

Číslo periodika v rámci svazku

N

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

222-232

Kód UT WoS článku

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EID výsledku v databázi Scopus

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