Regulation of Phase II Biotransformation Enzymes by Steroid Hormones

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F11%3A33117040" target="_blank" >RIV/61989592:15310/11:33117040 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Regulation of Phase II Biotransformation Enzymes by Steroid Hormones

Popis výsledku v původním jazyce

Phase II biotransformation enzymes conjugate xenobiotics using small, organic donor molecules, such as glutathione, UDPglucuronic acid, S-adenosyl-L-methionine, acetyl coenzyme A and amino acids (primarily glycine). These reactions generally resulted indetoxification by the loss of pharmacological activity and by quickening the elimination of xenobiotics from the body, however bioactivation is also known to be occured. Historically, it was placed more emphasis on research of phase I than of phase II enzymes. Nevertheless, it is well known that conjugation enzymes play an important role in drug and toxicant disposition since they can dramatically alter pharmacokinetics and therefore therapeutic efficacy and toxicity of drugs. In this context surprisingly, the exact regulation mechanism of phase II conjugation enzymes expression is not fully understood. However, available experimental data suggest that several transcriptional factors are involved in this process. In the current review,

Název v anglickém jazyce

Regulation of Phase II Biotransformation Enzymes by Steroid Hormones

Popis výsledku anglicky

Phase II biotransformation enzymes conjugate xenobiotics using small, organic donor molecules, such as glutathione, UDPglucuronic acid, S-adenosyl-L-methionine, acetyl coenzyme A and amino acids (primarily glycine). These reactions generally resulted indetoxification by the loss of pharmacological activity and by quickening the elimination of xenobiotics from the body, however bioactivation is also known to be occured. Historically, it was placed more emphasis on research of phase I than of phase II enzymes. Nevertheless, it is well known that conjugation enzymes play an important role in drug and toxicant disposition since they can dramatically alter pharmacokinetics and therefore therapeutic efficacy and toxicity of drugs. In this context surprisingly, the exact regulation mechanism of phase II conjugation enzymes expression is not fully understood. However, available experimental data suggest that several transcriptional factors are involved in this process. In the current review,

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Drug Metabolism

ISSN

1389-2002

e-ISSN

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Svazek periodika

12

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

20

Strana od-do

104-123

Kód UT WoS článku

000289085500004

EID výsledku v databázi Scopus

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