Phase II Drug Metabolism
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33116400" target="_blank" >RIV/61989592:15110/12:33116400 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/70883521:28110/12:43868798
Výsledek na webu
<a href="http://dx.doi.org/10.5772/29996" target="_blank" >http://dx.doi.org/10.5772/29996</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5772/29996" target="_blank" >10.5772/29996</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Phase II Drug Metabolism
Popis výsledku v původním jazyce
All organisms are constantly and unavoidably exposed to xenobiotics including both man-made and natural chemicals such as drugs, plant alkaloids, microorganism toxins, pollutants, pesticides, and other industrial chemicals. Formally, biotransformation ofxenobiotics as well as endogenous compounds is subdivided into phase I and phase II reactions. This chapter focuses on phase II biotransformation reactions (also called 'conjugation reactions') which generally serve as a detoxifying step in metabolism of drugs and other xenobiotics as well as endogenous substrates. On the other hand, these conjugations also play an essential role in the toxicity of many chemicals due to the metabolic formation of toxic metabolites such as reactive electrophiles. Gene polymorphism of biotransformation enzymes may often play a role in various pathophysiological processes. Conjugation reactions usually involve metabolite activation by a high-energy intermediate and have been classified into two general ty
Název v anglickém jazyce
Phase II Drug Metabolism
Popis výsledku anglicky
All organisms are constantly and unavoidably exposed to xenobiotics including both man-made and natural chemicals such as drugs, plant alkaloids, microorganism toxins, pollutants, pesticides, and other industrial chemicals. Formally, biotransformation ofxenobiotics as well as endogenous compounds is subdivided into phase I and phase II reactions. This chapter focuses on phase II biotransformation reactions (also called 'conjugation reactions') which generally serve as a detoxifying step in metabolism of drugs and other xenobiotics as well as endogenous substrates. On the other hand, these conjugations also play an essential role in the toxicity of many chemicals due to the metabolic formation of toxic metabolites such as reactive electrophiles. Gene polymorphism of biotransformation enzymes may often play a role in various pathophysiological processes. Conjugation reactions usually involve metabolite activation by a high-energy intermediate and have been classified into two general ty
Klasifikace
Druh
C - Kapitola v odborné knize
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicína pro regionální rozvoj a lidské zdroje</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název knihy nebo sborníku
Topics on Drug Metabolism
ISBN
978-953-51-0099-7
Počet stran výsledku
26
Strana od-do
35-60
Počet stran knihy
294
Název nakladatele
InTech
Místo vydání
Rijeka, Croatia
Kód UT WoS kapitoly
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