Preparation of 2-Phenyl-3-hydroxyquinoline-4(1H)-one-5-carboxamides as Potential Anticancer and Fluorescence Agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156130" target="_blank" >RIV/61989592:15310/15:33156130 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/15:33156130

Výsledek na webu

<a href="http://pubs.rsc.org/en/content/articlepdf/2015/ra/c5ra08733c" target="_blank" >http://pubs.rsc.org/en/content/articlepdf/2015/ra/c5ra08733c</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c5ra08733c" target="_blank" >10.1039/c5ra08733c</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Preparation of 2-Phenyl-3-hydroxyquinoline-4(1H)-one-5-carboxamides as Potential Anticancer and Fluorescence Agents

Popis výsledku v původním jazyce

Synthesis of 3-hydroxyquinoline-4(1H)-one derivatives bearing substituted phenyl in position 2 and variously substituted carboxamide group in position 5 is described, with use of 3-nitrophthalic anhydride, ?-haloketones and primary amines as the startingmaterials. The synthetic approach was inspired by the preparation of analogous derivatives reported previously. However, a different strategy had to be developed with the corresponding bis(phenacyl)-3-aminophthalates as the key intermediates . Synthesized hydroxyquinolinones, as well as their intermediates, were tested for their cytotoxic activity towards various cancer and non-malignant cell lines. The fluorescent properties of these compounds have also been evaluated. In both fields, interesting datawere obtained and compared to isomeric compounds that have been studied in the past.

Název v anglickém jazyce

Preparation of 2-Phenyl-3-hydroxyquinoline-4(1H)-one-5-carboxamides as Potential Anticancer and Fluorescence Agents

Popis výsledku anglicky

Synthesis of 3-hydroxyquinoline-4(1H)-one derivatives bearing substituted phenyl in position 2 and variously substituted carboxamide group in position 5 is described, with use of 3-nitrophthalic anhydride, ?-haloketones and primary amines as the startingmaterials. The synthetic approach was inspired by the preparation of analogous derivatives reported previously. However, a different strategy had to be developed with the corresponding bis(phenacyl)-3-aminophthalates as the key intermediates . Synthesized hydroxyquinolinones, as well as their intermediates, were tested for their cytotoxic activity towards various cancer and non-malignant cell lines. The fluorescent properties of these compounds have also been evaluated. In both fields, interesting datawere obtained and compared to isomeric compounds that have been studied in the past.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

RSC Advances (online)

ISSN

2046-2069

e-ISSN

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Svazek periodika

5

Číslo periodika v rámci svazku

MAY

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

48861-48867

Kód UT WoS článku

000355738300083

EID výsledku v databázi Scopus

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